{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:36:32Z","timestamp":1777444592314,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Effective prognostic markers are needed for antineutrophil cytoplasmic antibody-associated vasculitis (AAV). This study evaluated the clinical associations of serum vascular endothelial growth factor-A (sVEGF-A) and sVEGF-A\n                      <jats:sub>165<\/jats:sub>\n                      b (an antiangiogenic isoform of VEGF-A) concentrations with time to remission of AAV in a nationwide Japanese prospective follow-up cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We collected samples from patients with AAV who were enrolled in the nationwide Japanese cohort study (RemIT-JAV-RPGN). We measured sVEGF-A and sVEGF-A\n                      <jats:sub>165<\/jats:sub>\n                      b concentrations using enzyme-linked immunosorbent assays in 57 serum samples collected 6\u2009months before and after initiation of AAV treatment. Patients were classified based on AAV disease subtypes: microscopic polyangiitis, granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis (EGPA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Results revealed significant reductions in sVEGF-A and sVEGF-A\n                      <jats:sub>165<\/jats:sub>\n                      b concentrations in patients with microscopic polyangiitis and EGPA, respectively. However, despite the comparable concentrations of sVEGF-A and sVEGF-A\n                      <jats:sub>165<\/jats:sub>\n                      b during the 6\u2009months of treatment in granulomatosis with polyangiitis patients, correlation analysis revealed that the differences in log\n                      <jats:sub>2<\/jats:sub>\n                      -transformed concentrations of sVEGF-A and sVEGF-A\n                      <jats:sub>165<\/jats:sub>\n                      b were inversely correlated with time to remission in granulomatosis with polyangiitis patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These results suggest that sVEGF-A and -A\n                      <jats:sub>165<\/jats:sub>\n                      b can serve as potential markers of time to remission in patients with granulomatosis with polyangiitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004563220968371","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T03:47:38Z","timestamp":1603252058000},"page":"86-94","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Vascular endothelial growth factor (VEGF)-A and VEGF-A\n                    <sub>165<\/sub>\n                    b are associated with time to remission of granulomatosis with polyangiitis in a nationwide Japanese prospective cohort study"],"prefix":"10.1177","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-4302","authenticated-orcid":false,"given":"Ryosuke","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Department of Medical Technique, Nagoya University Hospital, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotake","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Fujita Health University, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-Ei","family":"Sada","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"},{"name":"Department of Clinical Epidemiology, Kochi Medical School, Kochi University, Nankoku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakatochi","sequence":"additional","affiliation":[{"name":"Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 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