{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:38:21Z","timestamp":1777444701741,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Fujita Health University Graduate School"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Progranulin (GP88) is an 88-kDa glycoprotein growth factor with important biological effects in tumorigenesis and tumour survival. We investigated the usefulness of measuring serum GP88 concentrations as a predictive biomarker for hepatocellular carcinoma in patients with viral hepatitis C after treatment with direct-acting antiviral agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured the serum GP88 concentrations by using a sandwich enzyme-linked immunoassay from 67 healthy control subjects and 29 patients (20 patients who did not develop hepatocellular carcinoma and 9 patients who developed hepatocellular carcinoma after treatment) with viral hepatitis C after treatment with asunaprevir and daclatasvir.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The serum GP88 concentrations of patients with chronic hepatitis C prior to antiviral treatment were significantly higher than those of healthy control subjects. After antiviral treatment, the serum GP88 concentrations of patients who eventually developed hepatocellular carcinoma were significantly higher than those who did not develop hepatocellular carcinoma. The changes in the serum GP88 concentrations before and after treatment in patients who developed hepatocellular carcinoma were significantly lower than those in patients who did not develop hepatocellular carcinoma. The cumulative incidence of hepatocellular carcinoma was significantly higher in either patients with high serum GP88 concentrations after treatment or those with small changes of serum GP88 concentrations pre- and post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sustained high concentrations of serum GP88 in patients treated with direct-acting antiviral agents are correlated with the risk of developing hepatocellular carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00045632211036723","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T02:27:37Z","timestamp":1626834457000},"page":"605-613","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum GP88 as a predictive biomarker for hepatocellular carcinoma in patients with viral hepatitis C after direct-acting antiviral agents"],"prefix":"10.1177","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-2099","authenticated-orcid":false,"given":"Hidekazu","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, Toyoake, Japan"},{"name":"Department of Clinical Laboratory, Fujita Health University Hospital, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Takemura","sequence":"additional","affiliation":[{"name":"Advanced Diagnostic System Research Laboratory, Fujita Health University, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Suetsugu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Naiki","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Gifu Municipal Hospital, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pathological Diagnosis, Gifu Municipal Hospital, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomita","family":"Eiichi","sequence":"additional","affiliation":[{"name":"Gifu Municipal Hospital, Gifu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginette","family":"Serrero","sequence":"additional","affiliation":[{"name":"R&D and Precision Antibody Divisions, A&G Pharmaceutical Inc., Columbia, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Matsunami","sequence":"additional","affiliation":[{"name":"Matsunami Research Park, 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