{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:29:08Z","timestamp":1783571348288,"version":"3.55.0"},"reference-count":6,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2023,5]]},"abstract":"\n Background<\/jats:title>\n There is limited published data on the stability of calcitonin, chromogranin A, thyroglobulin and anti-thyroglobulin antibodies in serum. The aim of this study was to determine stability at three temperature conditions over 7\u00a0days, reflecting current laboratory practices.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Surplus serum was stored at room temperature, refrigerated and in the freezer; for 1, 3, 5 and 7\u00a0days. Samples were analysed in batch and analyte concentrations compared to that of a baseline sample. Measurement Uncertainty of the assay was used to determine the Maximal Permissible Difference and thus the stability of the analyte.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Calcitonin was found to be stable for at least 7\u00a0days in the freezer but only 24\u00a0h refrigerated. Chromogranin A was stable for 3\u00a0days when refrigerated and only 24\u00a0h at room temperature. Thyroglobulin and anti-thyroglobulin antibodies were stable under all conditions for 7\u00a0days.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study has enabled the laboratory to increase the add-on time limit of Chromogranin A to 3\u00a0days, and up to 60\u00a0min for calcitonin and inform optimal storage and transportation conditions for referring specimens.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/00045632231160371","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T12:21:17Z","timestamp":1677846077000},"page":"212-216","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Stability assessment of serum tumour markers: Calcitonin, chromogranin A, thyroglobulin and anti-thyroglobulin antibodies"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4201-7217","authenticated-orcid":false,"given":"Sally","family":"Thirkettle","sequence":"first","affiliation":[{"name":"Christie Pathology Partnership, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Blaszczyk","sequence":"additional","affiliation":[{"name":"Christie Pathology Partnership, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Evans","sequence":"additional","affiliation":[{"name":"Christie Pathology Partnership, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wheatley","sequence":"additional","affiliation":[{"name":"Christie Pathology Partnership, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madihah","family":"Abbas","sequence":"additional","affiliation":[{"name":"Christie Pathology Partnership, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Russell","sequence":"additional","affiliation":[{"name":"Christie Pathology Partnership, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J","family":"Monaghan","sequence":"additional","affiliation":[{"name":"Christie Pathology Partnership, Manchester, UK"},{"name":"The Division of Cancer Sciences, University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"bibr1-00045632231160371","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(77)90030-0"},{"key":"bibr2-00045632231160371","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.04.026"},{"key":"bibr3-00045632231160371","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-0782"},{"key":"bibr4-00045632231160371","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.091371"},{"key":"bibr5-00045632231160371","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.07.003"},{"key":"bibr6-00045632231160371","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2020-0061"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632231160371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00045632231160371","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632231160371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:25:10Z","timestamp":1777379110000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00045632231160371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/00045632231160371"],"URL":"https:\/\/doi.org\/10.1177\/00045632231160371","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,3]]}}}