{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:20:30Z","timestamp":1785864030409,"version":"3.56.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gestational hypothyroidism has been shown to be associated with adverse pregnancy outcomes as well as adverse outcomes for the child. Thyroid hormones concentrations change in gestation, especially within the first trimester, so the results of thyroid function test often are outside non-pregnant reference ranges. The objective of this study was to establish the first trimester reference ranges for thyroid stimulating hormone (TSH) and free thyroxine (FT4) for pregnant women in Barcelona (Spain).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      It was a prospective study in which 673 women were recruited during their first trimester of gestation (8\u201313 weeks). Serum TSH, FT4 and antithyroid peroxidase antibodies (TPOAb) were measured with Atellica\n                      <jats:sup>\u00ae<\/jats:sup>\n                      IM 1600 (Siemens Healthineers). After excluding 418 women, the reference ranges for TSH and FT4 were calculated by the 2.5th and 97.5th percentiles. Potential variables examined in this study were age, body mass index (BMI), ethnicity, iodine supplementation and smoking habit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The reference ranges established on the Atellica\n                      <jats:sup>\u00ae<\/jats:sup>\n                      IM 1600 for the first trimester pregnancy in our population were 0.111 to 4.291\u00a0mIU\/L for TSH and 11.45 to 17.76\u00a0pmol\/L for FT4. No significant differences were found in thyroid hormones concentrations regarding maternal age (\u226430\u00a0years vs &gt;30\u00a0years) ( p = .117), iodine supplementation ( p = .683) and smoking habit ( p = .363). The prevalence of TPOAb was estimated at 10.0%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that in our local population, the optimal TSH upper reference limit in the first trimester of gestation was 4.3\u00a0mIU\/L, similar to that proposed by de ATA-2017 guideline (4.0\u00a0mIU\/L).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00045632231219387","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T21:43:20Z","timestamp":1700775800000},"page":"284-290","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Reference ranges of thyroid hormones during the first trimester in Catalan women using the Atellica\n                    <sup>\u00ae<\/sup>\n                    IM Solution Immunoassay Analyzer"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2865-2193","authenticated-orcid":false,"given":"Marina","family":"Giralt","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"D\u00edaz-Troyano","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immaculada","family":"Comas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Conesa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Reproductive Medicine, Maternal-Fetal Medicine Unit, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Zafon","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolism Research Unit (VHIR) and Department of Endocrinology, University Hospital Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Goya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Reproductive Medicine, Maternal-Fetal Medicine Unit, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"bibr1-00045632231219387","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0353"},{"key":"bibr2-00045632231219387","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00090"},{"key":"bibr3-00045632231219387","volume-title":"Consensus document on the management of thyroid dysfunction during pregnancy","author":"Velasco 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