{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:12:50Z","timestamp":1780791170630,"version":"3.54.1"},"reference-count":11,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>This is a case of a 61-year-old lady who presented to the lipid clinic with possible familial hypercholesterolaemia (Simon Broome Criteria). She was commenced on atorvastatin; however, 4\u00a0weeks later, she developed hepatitis, and therefore her atorvastatin was discontinued. Following that, her liver function tests normalized, and she was diagnosed with statin-induced hepatitis. Three years later, she was seen again in the lipid clinic with an uncontrolled lipid profile, and she was commenced on alirocumab, a Proprotein Convertase Subtilisin\/Kexin type 9 (PCSK9) inhibitor. A few days later, she developed hepatitis, and subsequently, the alirocumab was discontinued. She underwent a liver biopsy, which confirmed that she had Autoimmune Hepatitis (AIH) with presumed superimposed drug injury. This is the first reported case of autoimmune hepatitis associated with alirocumab.<\/jats:p>","DOI":"10.1177\/00045632241269657","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:56:54Z","timestamp":1722819414000},"page":"71-74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of autoimmune hepatitis associated with the PCSK9 inhibitor alirocumab"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9331-8474","authenticated-orcid":false,"given":"Amira","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Manchester University NHS Foundation Trust, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Manchester University NHS Foundation Trust, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-9238","authenticated-orcid":false,"given":"Eric S","family":"Kilpatrick","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Manchester University NHS Foundation Trust, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Manchester University NHS Foundation Trust, Manchester, UK"},{"name":"School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,4]]},"reference":[{"key":"bibr1-00045632241269657","volume-title":"Clinical chemistry","author":"Marshall WJ","year":"2021"},{"key":"bibr2-00045632241269657","volume-title":"Familial hypercholesterolaemia: identification and management, NICE guidelines (CG71)","year":"2019"},{"key":"bibr3-00045632241269657","volume-title":"Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia, Technology appraisal guidance","year":"2016"},{"key":"bibr4-00045632241269657","volume-title":"Alirocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia, Technology appraisal guidance","year":"2016"},{"issue":"1","key":"bibr5-00045632241269657","doi-asserted-by":"crossref","first-page":"32","DOI":"10.31083\/j.rcm.2018.01.890","volume":"19","author":"Roth MA","year":"2018","journal-title":"Rev Cardiovasc Med"},{"issue":"7","key":"bibr6-00045632241269657","first-page":"789","volume":"49","author":"Aivazian K","year":"2017","journal-title":"The Journal of Royal of Colleague of Pathologists of Australia"},{"key":"bibr7-00045632241269657","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1748-1"},{"key":"bibr8-00045632241269657","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512463485"},{"key":"bibr9-00045632241269657","unstructured":"ODYSSEY outcomes: evaluation of cardiovascular outcomes after an acute coronary syndrome during treatment with alirocumab, ClinicalTrials.gov ID NCT01663402."},{"key":"bibr10-00045632241269657","unstructured":"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548190\/"},{"key":"bibr11-00045632241269657","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(23)03201-1"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632241269657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00045632241269657","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632241269657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:25:28Z","timestamp":1777379128000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00045632241269657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,4]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/00045632241269657"],"URL":"https:\/\/doi.org\/10.1177\/00045632241269657","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,4]]}}}