{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T20:18:55Z","timestamp":1784319535684,"version":"3.55.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100014823","name":"VGH & UBC Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014823","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>IgG4-related disease (IgG4-RD) is an inflammatory disease that can clinically mimic pancreatic and hepatobiliary cancer. Serum carbohydrate antigen 19-9 (CA19-9) is a tumour marker that is frequently used to aid in the diagnosis of biliary cancer. There have been reported cases that patients with IgG4-RD also have elevated CA19-9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study has two components, first, a quality assurance component that observes paired IgG4 and CA19-9 measurements from patients with unknown diagnoses were compared to determine if serum IgG4 interferes with CA19-9 measurement. In addition, a mixing study is used to investigate if high levels of IgG4 interfered with CA19-9 measurements. Second, a retrospective chart review was performed to compare patients diagnosed with IgG4-RD with normal versus elevated CA19-9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 487 unique individuals with paired measurements, no association between CA19-9 and serum IgG4 was found. Mixing studies revealed no interference. Among 20 patients with IgG4-RD, 11 had elevated CA19-9 (median 150\u00a0kU\/L) and nine had normal CA19-9. There was no difference in bilirubin between the two groups (63.2\u00a0\u00b5mol\/L vs 39.4\u00a0\u00b5mol\/L,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .47).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is no relationship between CA19-9 and serum IgG4. Patients with IgG4-RD and elevated CA19-9 did not have higher bilirubin than those with normal CA19-9. Together, these results suggest that elevated CA19-9 in IgG4-RD may be related to the disease rather than to interference from high serum IgG4 or from biliary obstruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00045632251370803","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T06:34:36Z","timestamp":1754634876000},"page":"132-140","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Elevated CA19-9 in IgG4-related disease"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2721-5306","authenticated-orcid":false,"given":"Derrick HY","family":"Chong","sequence":"first","affiliation":[{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Mattman","sequence":"additional","affiliation":[{"name":"St. Paul\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Dou","sequence":"additional","affiliation":[{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"So","sequence":"additional","affiliation":[{"name":"Artus Health Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J","family":"Lim","sequence":"additional","affiliation":[{"name":"BC Cancer"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Shi","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cleve","sequence":"additional","affiliation":[{"name":"Fraser Health Authority"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric CS","family":"Lam","sequence":"additional","affiliation":[{"name":"University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J","family":"Telford","sequence":"additional","affiliation":[{"name":"University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke YC","family":"Chen","sequence":"additional","affiliation":[{"name":"University of British Columbia"},{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mollie N","family":"Carruthers","sequence":"additional","affiliation":[{"name":"Arthritis Research Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050219-034449"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-021-00957-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30169-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2018.14319"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41120"},{"key":"e_1_3_3_7_2","first-page":"105","article-title":"The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: an evidence based appraisal","volume":"3","author":"Ballehaninna UK","year":"2012","unstructured":"Ballehaninna UK, Chamberlain RS. The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: an evidence based appraisal. J Gastrointest Oncol 2012; 3: 105\u2013119.","journal-title":"J Gastrointest Oncol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65720-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327092"},{"key":"e_1_3_3_10_2","first-page":"1322","article-title":"Serum level of Ca 19-9 increases ability of IgG4 test to distinguish patients with autoimmune pancreatitis from those with pancreatic carcinoma","volume":"59","author":"van Heerde MJ","year":"2014","unstructured":"van Heerde MJ, Buijs J, Hansen BE, et al. Serum level of Ca 19-9 increases ability of IgG4 test to distinguish patients with autoimmune pancreatitis from those with pancreatic carcinoma. Dig Dis Sci 2014; 59: 1322\u20131329.","journal-title":"Dig Dis Sci"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2014.07.010"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001637"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.282319"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632251370803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00045632251370803","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632251370803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:25:45Z","timestamp":1777379145000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00045632251370803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/00045632251370803"],"URL":"https:\/\/doi.org\/10.1177\/00045632251370803","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]}}}