{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:44:20Z","timestamp":1777445060620,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      haemolysis is a recurrent problem in emergency department samples. Potassium is one of the most critical tests and sensitive to increasing levels of\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      haemolysis. Haemolysis results in a large number of invalidated potassium test results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We set up an alert system to detect the risk of dyskalaemia based on potassium value and haemolysis index (HI). We retrospectively evaluated the effectiveness of the alert system for haemolysed blood samples from the emergency department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      54 605 samples were included. Women more frequently had a sample with a high HI value, resulting in the invalidation of a potassium test result (3.22% vs 2.35%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In the case of haemolysed samples, the frequency of alerts for hyperkalemia risk was similar in women and men. Hypokalaemia was significantly more frequent in women than in men (12.71% vs 9.38%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Among the haemolyzed samples, no hypokalaemia risk alerts were observed and 42 patients had a hyperkalaemia risk alert. For these patients, the potassium value of a second sample was significantly higher in patients with an alert on the first sample (4.85\u00a0mmol\/L vs 4.0\u00a0mmol\/L,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), with a higher rate of hyperkalaemia (57.14% vs 4.76%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and critical hyperkalaemia (17.86% vs 0.3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Negative predictive value and positive predictive value to detect hyperkalaemia were 90.4% [89.6\u201391] and 41.3% [25.5%\u201359.1%].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our alert system was effective to detect the risk of hyperkalemia, and could help clinicians to better target patients requiring repeat sampling for potassium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00045632251372764","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T12:51:24Z","timestamp":1755175884000},"page":"159-166","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-life evaluation of an alert system to detect the risk of unreported dyskaelemia in haemolysed blood samples from a hospital emergency department"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3069-6208","authenticated-orcid":false,"given":"Valery","family":"Brunel","sequence":"first","affiliation":[{"name":"Rouen University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Fettig","sequence":"additional","affiliation":[{"name":"Rouen University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc Marie","family":"Joly","sequence":"additional","affiliation":[{"name":"Rouen University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-6941","authenticated-orcid":false,"given":"Guillaume","family":"Feugray","sequence":"additional","affiliation":[{"name":"Rouen University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0120-5142","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Fraissinet","sequence":"additional","affiliation":[{"name":"Rouen University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Girot","sequence":"additional","affiliation":[{"name":"Rouen University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2011.011099"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2019.1664391"},{"key":"e_1_3_5_4_2","first-page":"487","article-title":"Potassium disorders: hypokalemia and hyperkalemia","volume":"92","author":"Viera AJ","year":"2015","unstructured":"Viera AJ, Wouk N. Potassium disorders: hypokalemia and hyperkalemia. Am Fam Physician 2015; 92: 487\u2013495.","journal-title":"Am Fam Physician"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-1104"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-0354"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.03.043"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236934"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.12.010"},{"key":"e_1_3_5_10_2","first-page":"46","article-title":"Etiology and symptoms of severe hypokalemia in emergency department patients","volume":"21","author":"Marti G","year":"2014","unstructured":"Marti G, Schwarz C, Leichtle AB, et al. Etiology and symptoms of severe hypokalemia in emergency department patients. Eur J Emerg Med 2014; 21: 46\u201351.","journal-title":"Eur J Emerg Med"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2013.02.010"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000360134"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.15-3-239"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl227"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0400-OA"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.08.002"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2012.012032"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-022278"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2014.966898"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2014.04.019"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2015.01.047"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-068387"},{"key":"e_1_3_5_23_2","first-page":"705","article-title":"[Hemolysis interferences on frequently required stat analysis: a French multicentric study]","volume":"73","author":"Poupon C","year":"2015","unstructured":"Poupon C, Lef\u00e8vre G, Ngo-Fran\u00e7ois S, et al. [Hemolysis interferences on frequently required stat analysis: a French multicentric study]. Ann Biol Clin 2015; 73: 705\u2013716.","journal-title":"Ann Biol Clin"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2020.1855363"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632251372764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00045632251372764","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632251372764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:25:45Z","timestamp":1777379145000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00045632251372764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/00045632251372764"],"URL":"https:\/\/doi.org\/10.1177\/00045632251372764","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]}}}