{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:11:37Z","timestamp":1778130697267,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diagnosing acute heart failure in patients presenting with acute dyspnea remains challenging. Current methods, including natriuretic peptide measurement and echocardiography, are time-consuming and not always immediately accessible. A novel biomarker, FILDARIA, may complement natriuretic peptides and enable faster diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study (ClinicalTrials.gov: NCT01024049), samples were collected from 235 patients diagnosed via echocardiography: 89 with non-cardiac dyspnea (NCD), 55 with chronic heart failure (CHF), and 91 with acute heart failure (AHF). Levels of BNP and FILDARIA in each patient were measured using both ELISA and lateral flow assay tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      BNP levels were significantly elevated in AHF and CHF patients compared to NCD patients (905 vs 58\u00a0pg\/mL,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .0001; and 447 vs 58\u00a0pg\/mL,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .0001, respectively). Similarly, FILDARIA levels were markedly higher in AHF and CHF patients than in NCD patients (1493 vs 223\u00a0ng\/mL,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .0001; and 800 vs 223\u00a0ng\/mL,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .0001, respectively). The FILDARIA heart failure diagnostic rapid test device accurately identified all 91 AHF patients and correctly excluded 88 of 89 NCD patients, yielding one false positive. Overall diagnostic accuracy was 99.4% (95% CI: 96.9%\u201399.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      FILDARIA biomarker demonstrates strong potential as a rapid\n                      <jats:underline>diagnostic<\/jats:underline>\n                      tool for AHF in patients with acute dyspnea. Its high accuracy and compatibility with whole blood could make it an excellent solution for point-of-care testing. Further multicentre research could facilitate wider clinical use and clarify its utility in areas such as\n                      <jats:underline>prognosis<\/jats:underline>\n                      (ClinicalTrials.gov: NCT01024049).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00045632251378035","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T01:31:57Z","timestamp":1756431117000},"page":"228-239","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic accuracy and rapid testing of a novel acute heart failure biomarker: A laboratory evaluation and comparison with natriuretic peptides"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5427-6528","authenticated-orcid":false,"given":"Kevin","family":"Rouet","sequence":"first","affiliation":[{"name":"Association pour le D\u00e9veloppement de la Recherche en Cardiologie Mol\u00e9culaire et Clinique"},{"name":"Grigore T. Popa University of Medicine and Pharmacy"},{"name":"Regional Institute of Oncology (IRO)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Rouet","sequence":"additional","affiliation":[{"name":"Association pour le D\u00e9veloppement de la Recherche en Cardiologie Mol\u00e9culaire et Clinique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Koukoui","sequence":"additional","affiliation":[{"name":"Association pour le D\u00e9veloppement de la Recherche en Cardiologie Mol\u00e9culaire et Clinique"},{"name":"Service de R\u00e9adaptation Cardiaque Centre Hospitalier Sud Francilien"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Galinier","sequence":"additional","affiliation":[{"name":"Toulouse University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-024-01046-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2004.04.016"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HHF.0b013e318291329a"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-022-00551-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2007.07.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610173351603"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13646"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239318"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2848"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.10.017"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2009.05.019"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-008-9109-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.4.835"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.059"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.021"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.010"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13703"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.021"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020233"},{"key":"e_1_3_3_21_2","first-page":"476","article-title":"Prognostic utility of NT-proBNP greater than 70,000 pg\/mL in patients with end stage renal disease","volume":"15","author":"Perez-Downes J","year":"2018","unstructured":"Perez-Downes J, Palacio C, Ibrahim S, et al. Prognostic utility of NT-proBNP greater than 70,000 pg\/mL in patients with end stage renal disease. J Geriatr Cardiol 2018; 15: 476\u2013478.","journal-title":"J Geriatr Cardiol"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.038"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306565"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.128"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.01.011"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.21.0391"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632251378035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00045632251378035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632251378035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:24:54Z","timestamp":1778127894000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00045632251378035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/00045632251378035"],"URL":"https:\/\/doi.org\/10.1177\/00045632251378035","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,8]]}}}