{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:40:36Z","timestamp":1792658436615,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the stability of commonly used biomarkers in whole blood under various storage conditions, in order to assess their suitability for home-based blood collection in remote care settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Whole blood samples were stored at 4\u20138\u00b0C, 20\u201325\u00b0C and 37\u00b0C for up to 72\u00a0h. Six pooled samples and two healthy volunteer samples were aliquoted and analysed at four time points (T0, T24, T48 and T72\u00a0h). A panel of 47 routine chemistry and immunochemistry biomarkers was measured in all samples. Recoveries relative to T0 were compared to within subject coefficients of variation of the individual biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most biomarkers remained stable at refrigerated and room temperature conditions up to 72\u00a0h with a subset of biomarkers, mostly proteins and tumour markers also showing good to acceptable stability at 37\u00b0C. Several biomarkers, including potassium, inorganic phosphate and iron, consistently fell outside acceptable limits under multiple conditions. Others, such as sodium, calcium, ferritin, aspartate aminotransferase and cytokeratin fragment 21-1, were unstable only at 37\u00b0C. A few transient deviations were observed, but these were not consistent over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Home-based blood sampling is feasible for a broad range of biomarkers, provided that heat exposure during transport is minimised. These findings are a first step in the further validation of selected analytes under real-world, capillary blood sampling conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00045632261424746","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T01:41:21Z","timestamp":1770082881000},"page":"375-381","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the stability of whole blood samples for remote health care applications towards reliable home-based blood testing"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8710-094X","authenticated-orcid":false,"given":"M. H. 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Noncommunicable diseases. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/noncommunicable-diseases (2023 Accessed 15 April 2025)."},{"key":"e_1_3_5_3_2","volume-title":"Global strategy on human resources for health: workforce 2030","author":"World Health Organization","year":"2016","unstructured":"World Health Organization. Global strategy on human resources for health: workforce 2030. Geneva: WHO, 2016."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-024-00148-2"},{"issue":"23","key":"e_1_3_5_5_2","first-page":"e82","article-title":"Covid-19 and health care\u2019s digital revolution","volume":"382","author":"Sirina K","year":"2020","unstructured":"Sirina K, Andrea J, Kevin S. Covid-19 and health care\u2019s digital revolution. 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