{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:46:55Z","timestamp":1792601215720,"version":"4.5.0"},"reference-count":7,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Clin Biochem"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Combination of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) is useful to exclude intracranial injury after mild traumatic brain injury (mTBI). We evaluated the diagnostic performance of the novel regulatory-approved VIDAS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      TBI assay for this purpose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients under 65\u00a0years of age presenting to the Emergency Department with TBI, Glasgow Coma score 13\u201315, completed head computed tomography (CT) scan and blood collected within 12\u00a0hours of injury were included. UCH-L1\/GFAP levels were analysed using prespecified cutoffs and combined into a single result and evaluated against CT findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      78 enrolled participants were analysed. Intracranial injury was detected in 4 patients. VIDAS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      TBI test achieved a sensitivity and negative predictive value of 100%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The VIDAS TBI assay showed potential as a rule-out test in this exploratory cohort; however, estimates were based on only four CT-positive cases and require confirmation in larger prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00045632261497264","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:36:30Z","timestamp":1790858190000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Accuracy of the novel automated VIDAS TBI (GFAP, UCH-L1) assay for ruling out acute intracranial traumatic lesions in patients under 65 years of age with mild traumatic brain injury in an Emergency Department: An exploratory study"],"prefix":"10.1177","author":[{"given":"Eva","family":"P\u00e9rez Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"University Hospital Santa Luc\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Montoro Jorquera","sequence":"additional","affiliation":[{"name":"University Hospital Santa Luc\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Noblia","sequence":"additional","affiliation":[{"name":"University Hospital Santa Luc\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fern\u00e1ndez Reina","sequence":"additional","affiliation":[{"name":"University Hospital Santa Luc\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Valle Alonso","sequence":"additional","affiliation":[{"name":"University Hospital Santa Luc\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Manuel","family":"G\u00f3mez Morales","sequence":"additional","affiliation":[{"name":"University Hospital Santa Luc\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"S\u00e1nchez Gil","sequence":"additional","affiliation":[{"name":"University Hospital Santa Luc\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Gonz\u00e1lez Morales","sequence":"additional","affiliation":[{"name":"University Hospital Santa Luc\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3028-3198","authenticated-orcid":false,"given":"Luis","family":"Garc\u00eda de Guadiana-Romualdo","sequence":"additional","affiliation":[{"name":"University Hospital Santa Luc\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/16501960410023732"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072149"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2024.0581"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2025.03.018"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105477"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jalm.2019.031393"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2024-1034"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632261497264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00045632261497264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00045632261497264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:22:57Z","timestamp":1792599777000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00045632261497264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":7,"alternative-id":["10.1177\/00045632261497264"],"URL":"https:\/\/doi.org\/10.1177\/00045632261497264","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"00045632261497264"}}