{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:27:07Z","timestamp":1777422427496,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1-6","license":[{"start":{"date-parts":[[1979,1,1]],"date-time":"1979-01-01T00:00:00Z","timestamp":283996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:p>Cyclic adenosine 3\u2032, 5\u2032 monophosphate (cyclic-AMP) has been estimated in mucosal biopsy samples removed from the descending colon and rectum at endoscopy to investigate the possibility of using this substance for monitoring pre-malignant changes in the large bowel. Four groups of patients have been studied: those with normal large bowel and rectal mucosa; those with non-malignant inflammatory bowel disease; those with an adenomatous polyp in the descending colon or sigmoid colon; and those with a rectal adenocarcinoma. No difference was found in the cyclic-AMP content of \u2018normal\u2019 rectal mucosa, \u2018normal\u2019 colonic mucosa, \u2018diseased\u2019 colonic mucosa, carcinomas, and uninvolved mucosa adjacent to the polyps. Less cyclic-AMP was found in the polyps than in adjacent uninvolved mucosa. Conversely, more cyclic-AMP was found in the carcinomas than in adjacent uninvolved mucosa. It is concluded that although cyclic-AMP may be a very useful parameter for delineating the extent of the disease in individual patients, it is not a suitable biochemical marker for the screening of neoplastic changes in the large bowel in the population as a whole.<\/jats:p>","DOI":"10.1177\/000456327901600129","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:56:30Z","timestamp":1391619390000},"page":"127-130","source":"Crossref","is-referenced-by-count":2,"title":["Cyclic Adenosine 3\u2032, 5\u2032 Monophosphate: A Possible Indicator of Premalignant Changes in the Large Bowel"],"prefix":"10.1177","volume":"16","author":[{"given":"A. L.","family":"Latner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tregoning","sequence":"additional","affiliation":[{"name":"University Departments of Clinical Biochemistry and Surgery, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1979,1,1]]},"reference":[{"key":"bibr1-000456327901600129","volume-title":"Surgical Pathology","author":"Ackerman L. 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In Cold Spring Harbor Conferences on Cell Proliferation, Vol. 1, edited by Clarkson B., Baserga R., pp. 571\u2013579."},{"key":"bibr15-000456327901600129","first-page":"121","volume-title":"Advances in Internal Medicine","volume":"20","author":"Sherlock P.","year":"1975"},{"key":"bibr16-000456327901600129","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(77)90290-2"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456327901600129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456327901600129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:20:06Z","timestamp":1777375206000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456327901600129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":16,"journal-issue":{"issue":"1-6","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1177\/000456327901600129"],"URL":"https:\/\/doi.org\/10.1177\/000456327901600129","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}