{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:28:31Z","timestamp":1777422511456,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1980,5,1]],"date-time":"1980-05-01T00:00:00Z","timestamp":325987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1980,5]]},"abstract":"<jats:p>\n                    Nervous-system specific aldolase C has been detected in human cerebrospinal fluid (CSF) by radioimmunoassay. Measurement of 138 samples of CSF showed a mean level of 92 \u00b1 28 ng\/ml. There was no correlation between the level of CSF aldolase C and the CSF total protein, albumin, IgG, or IgA levels. Aldolase C immunoreactivity present in concentrated CSF diluted out in parallel with the standard curve in the assay and showed an elution profile on ion-exchange and gel filtration chromatography similar to that of aldolase present in whole human brain extracts. Addition of known quantities of purified aldolase C\n                    <jats:sub>4<\/jats:sub>\n                    to CSF gave quantitative recovery on subsequent radioimmunoassay. Measurement of aldolase C in the CSF of 66 patients with neurological disorders showed several patients with levels considerably in excess of 120 ng\/ml, but there was no statistically significant difference in the mean levels between groups of patients with different diseases.\n                  <\/jats:p>","DOI":"10.1177\/000456328001700302","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"110-113","source":"Crossref","is-referenced-by-count":20,"title":["Immunoreactive Aldolase C in Cerebrospinal Fluid of Patients with Neurological Disorders"],"prefix":"10.1177","volume":"17","author":[{"given":"V J C","family":"Willson","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Wales, Heath Park, Cardiff CF4 4XN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I N F","family":"McQueen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Wales, Heath Park, Cardiff CF4 4XN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QR"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1980,5,1]]},"reference":[{"key":"bibr1-000456328001700302","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.28.10.828"},{"key":"bibr2-000456328001700302","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(78)90402-3"},{"key":"bibr3-000456328001700302","author":"Willson V J C","journal-title":"Ann Clin Biochem"},{"key":"bibr4-000456328001700302","doi-asserted-by":"publisher","DOI":"10.1042\/bj0910222"},{"key":"bibr5-000456328001700302","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(80)90251-X"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328001700302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328001700302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:20:27Z","timestamp":1777375227000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456328001700302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,5]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1980,5]]}},"alternative-id":["10.1177\/000456328001700302"],"URL":"https:\/\/doi.org\/10.1177\/000456328001700302","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,5]]}}}