{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:59:50Z","timestamp":1777424390393,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1981,3,1]],"date-time":"1981-03-01T00:00:00Z","timestamp":352252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1981,3]]},"abstract":"<jats:p>High-density lipoprotein (HDL) cholesterol, total cholesterol, and triglyceride concentrations were measured in fasting blood samples from 74 controls and 185 patients with untreated primary hyperlipoproteinaemia. The mean HDL cholesterol levels and the total cholesterol: HDL cholesterol ratios were significantly different between male and female subjects. Only patients with Fredrickson type IV hyperlipoproteinaemia had HDL cholesterol concentrations significantly lower than the controls, but all subjects with hyperlipoproteinaemia had total: HDL cholesterol ratios significantly higher than control values.<\/jats:p>\n                  <jats:p>Subsequent investigations were performed on 31 patients during treatment of the hyperlipoproteinaemia by diet alone or in combination with clofibrate. Responses were variable, but generally improvements in the concentrations of triglyceride and total cholesterol were accompanied by an unchanged or decreased total: HDL cholesterol ratio, although there was not necessarily an increase in the HDL cholesterol itself.<\/jats:p>","DOI":"10.1177\/000456328101800203","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"71-75","source":"Crossref","is-referenced-by-count":0,"title":["Pre- and Post-Treatment Values of HDL Cholesterol and Total: HDL Cholesterol Ratio in Hyperlipoproteinaemic Subjects"],"prefix":"10.1177","volume":"18","author":[{"given":"John K","family":"Sale","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Poole General Hospital, Poole, Dorset"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Poole General Hospital, Poole, Dorset"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1981,3,1]]},"reference":[{"key":"bibr1-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(51)90183-0"},{"key":"bibr2-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92376-4"},{"key":"bibr3-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602052940601"},{"key":"bibr4-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92274-7"},{"key":"bibr5-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.5.767"},{"key":"bibr6-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92638-2"},{"key":"bibr7-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(77)90127-7"},{"key":"bibr8-000456328101800203","unstructured":"McTaggart F, Sennitt CM, Dixon RM, Williams JM, Stone MC. A study of two precipitation techniques of HDL cholesterol. In:\n                      Symposium on precipitation techniques as an aid to the study of biochemical abnormalities related to atherosclerosis.\n                      Alderley Edge: ICI, 1978; 2\u20134."},{"key":"bibr9-000456328101800203","first-page":"891","volume":"43","author":"Beaumont JL","year":"1970","journal-title":"Bull WHO"},{"key":"bibr10-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(77)90082-0"},{"key":"bibr11-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(79)90176-X"},{"key":"bibr12-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90063-1"},{"key":"bibr13-000456328101800203","first-page":"39","author":"Castelli WP","year":"1977","journal-title":"Current Prescribing"},{"key":"bibr14-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"bibr15-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91863-9"},{"key":"bibr16-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92007-5"},{"key":"bibr17-000456328101800203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91760-4"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328101800203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328101800203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:26:42Z","timestamp":1777375602000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456328101800203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,3]]}},"alternative-id":["10.1177\/000456328101800203"],"URL":"https:\/\/doi.org\/10.1177\/000456328101800203","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,3]]}}}