{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:00:25Z","timestamp":1777424425754,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1981,7,1]],"date-time":"1981-07-01T00:00:00Z","timestamp":362793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1981,7]]},"abstract":"<jats:p>The effect that synthetic steroid components of different oral contraceptives have on the assay system for measurement of sex hormone binding globulin (SHBG)-binding capacity, has been examined. Interference with the assay was not demonstrable at therapeutic levels of the drugs. d-Norgestrel was the only steroid studied which bound to SHBG with an affinity comparable to the endogenous sex hormones; it also tended to decrease SHBG-binding capacity, whereas preparations containing low levels of norethisterone increased the binding capacity. We suggest that measurement of changes in SHBG-binding capacity in subjects taking oral contraceptives may prove useful in indicating changes in sex hormone balance, particularly in view of the well-recognised side-effect of these drugs.<\/jats:p>","DOI":"10.1177\/000456328101800407","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"226-231","source":"Crossref","is-referenced-by-count":13,"title":["Sex Hormone Binding Globulin: Effect of Synthetic Steroids on the Assay and Effect of Oral Contraceptives"],"prefix":"10.1177","volume":"18","author":[{"given":"Susan M","family":"Bowles","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, Southend General Hospital, Westcliff-on-Sea, Essex"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Southend General Hospital, Westcliff-on-Sea, Essex"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1981,7,1]]},"reference":[{"key":"bibr1-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1974.tb03298.x"},{"key":"bibr2-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1979.tb03031.x"},{"key":"bibr3-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-34-6-983"},{"key":"bibr4-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-27-7-1012"},{"key":"bibr5-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-29-11-1470"},{"key":"bibr6-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1038\/240038a0"},{"key":"bibr7-000456328101800407","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-134-34864"},{"key":"bibr8-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6048.1354"},{"key":"bibr9-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(75)80019-9"},{"key":"bibr10-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(75)90050-5"},{"key":"bibr11-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-37-6-873"},{"key":"bibr12-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-36-4-706"},{"key":"bibr13-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1972.tb12193.x"},{"key":"bibr14-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(74)90099-7"},{"key":"bibr15-000456328101800407","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-43-1-244"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328101800407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328101800407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:26:48Z","timestamp":1777375608000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456328101800407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,7]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,7]]}},"alternative-id":["10.1177\/000456328101800407"],"URL":"https:\/\/doi.org\/10.1177\/000456328101800407","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,7]]}}}