{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:01:05Z","timestamp":1777424465559,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1981,11,1]],"date-time":"1981-11-01T00:00:00Z","timestamp":373420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1981,11]]},"abstract":"<jats:p>We measured Concanavalin A (Con A) non-binding alphafetoprotein in amniotic fluid from 21 normal pregnancies and 20 abnormal pregnancies (complicated by anencephaly, spina bifida, or exomphalos) using small Con A-sepharose chromatography columns. There was a highly significant difference between percentage non-binding alphafetoprotein levels for pregnancies with a normal outcome (mean result 32%; range 18\u201347%) and pregnancies complicated by a neural tube defect or exomphalos (mean 14%; range 7\u201320%). The test is therefore of potential value in cases where there is uncertainty over the interpretation of total amniotic fluid alphafetoprotein levels.<\/jats:p>","DOI":"10.1177\/000456328101800605","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"350-352","source":"Crossref","is-referenced-by-count":3,"title":["Affinity Chromatography of Amniotic Fluid Alphafetoprotein Using Concanavalin A-Sepharose"],"prefix":"10.1177","volume":"18","author":[{"given":"Jennifer A","family":"Noyes","sequence":"first","affiliation":[{"name":"Department of Human Reproduction and Obstetrics, University of Southampton"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology and Human Metabolism, University of Southampton"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1981,11,1]]},"reference":[{"key":"bibr1-000456328101800605","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6202.1402"},{"key":"bibr2-000456328101800605","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(79)90488-4"},{"key":"bibr3-000456328101800605","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6168.920"},{"key":"bibr4-000456328101800605","first-page":"267","volume":"2","author":"Brock DJH.","year":"1976","journal-title":"Lancet"},{"key":"bibr5-000456328101800605","first-page":"2651","volume":"37","author":"Smith CJ","year":"1977","journal-title":"Cancer Res."},{"key":"bibr6-000456328101800605","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6193.768-a"},{"key":"bibr7-000456328101800605","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/26.12.1656"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328101800605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328101800605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:26:51Z","timestamp":1777375611000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456328101800605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,11]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1981,11]]}},"alternative-id":["10.1177\/000456328101800605"],"URL":"https:\/\/doi.org\/10.1177\/000456328101800605","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,11]]}}}