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In breast cancer, for example, we have found that the most sensitive method for routine screening for metastases is by using chest x-ray and clinical examination, liver function tests, and carcinoembryonic antigen measurements. We are now examining other methods for detecting metastases using immunocytochemistry in cytological preparations of bone marrow and attempting to raise monoclonal antibodies to breast cancer cells. In lung cancer, the major effort has been directed towards characterisation of large-molecular-weight ectopic hormones, particularly calcitonin.<\/jats:p>","DOI":"10.1177\/000456328201900415","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"263-268","source":"Crossref","is-referenced-by-count":7,"title":["Markers in Breast and Lung Cancer"],"prefix":"10.1177","volume":"19","author":[{"given":"R C","family":"Coombes","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research (London Branch), Royal Marsden Hospital, Sutton, Surrey SM2 5PX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Dearnaley","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research (London Branch), Royal Marsden Hospital, Sutton, Surrey SM2 5PX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morag L","family":"Ellison","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research (London Branch), Royal Marsden Hospital, Sutton, Surrey SM2 5PX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Neville","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research (London Branch), Royal Marsden Hospital, Sutton, Surrey SM2 5PX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,7,1]]},"reference":[{"key":"bibr1-000456328201900415","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91719-6"},{"key":"bibr2-000456328201900415","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.32.1.35"},{"key":"bibr3-000456328201900415","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.34.12.1326"},{"key":"bibr4-000456328201900415","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1980.250"},{"key":"bibr5-000456328201900415","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1981.152"},{"key":"bibr6-000456328201900415","author":"Buckman R","year":"1980","journal-title":"Proc Europ Soc Med Oncol Nice"},{"key":"bibr7-000456328201900415","doi-asserted-by":"publisher","DOI":"10.1038\/256495a0"},{"key":"bibr8-000456328201900415","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/57.5.1199"},{"key":"bibr9-000456328201900415","first-page":"194","volume":"42","author":"Williams JC","year":"1980","journal-title":"Br J Cancer"},{"key":"bibr10-000456328201900415","doi-asserted-by":"publisher","DOI":"10.1016\/0007-0971(78)90056-6"},{"key":"bibr11-000456328201900415","unstructured":"Sappino A-P, Ellison ML, Carter SM, Smith IE. Prognostic value of tumour markers at presentation for treated small cell carcinoma of the lung. 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