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Patients received either 10 mg i.v. morphine followed by 10 mg MST or 20 mg i.v. morphine followed by 2\u00d710 mg MST tablets. Systemic clearance of morphine was low, being about 3 ml\/min\/kg after both intravenous and oral administration. The ratio of the areas under the concentration\u2013time curve for MST relative to that for i.v. morphine was about 1:1 for 20 mg doses, but was significantly greater than 1:1 for 10 mg doses. The results suggest high oral systemic availability for morphine and low hepatic morphine metabolism.<\/jats:p>","DOI":"10.1177\/000456328502200303","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"226-231","source":"Crossref","is-referenced-by-count":4,"title":["Systemic Availability of Oral Slow-Release Morphine in Man"],"prefix":"10.1177","volume":"22","author":[{"given":"R A","family":"Moore","sequence":"first","affiliation":[{"name":"Nuffield Department of Clinical Biochemistry, Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"McQuay","sequence":"additional","affiliation":[{"name":"Department of Oxford Regional Pain Relief Unit, Abingdon Hospital, Abingdon, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R E S","family":"Bullingham","sequence":"additional","affiliation":[{"name":"Department of Anaesthetics, Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Biochemistry, Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Allen","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Biochemistry, Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1985,5,1]]},"reference":[{"key":"bibr1-000456328502200303","doi-asserted-by":"publisher","DOI":"10.3109\/03602537508993748"},{"key":"bibr2-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1002\/cpt197824152"},{"key":"bibr3-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(76)90256-2"},{"key":"bibr4-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1982.tb01845.x"},{"key":"bibr5-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1984.88"},{"key":"bibr6-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1983.180"},{"key":"bibr7-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(81)80005-4"},{"key":"bibr8-000456328502200303","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0022-3565(25)31312-1","volume":"206","author":"Iwamoto K","year":"1978","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr9-000456328502200303","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0022-3565(25)33015-6","volume":"221","author":"Knodell RG","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr10-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90369-2"},{"key":"bibr11-000456328502200303","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0022-3565(25)33411-7","volume":"223","author":"Schali C","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr12-000456328502200303","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198019020-00002"},{"key":"bibr13-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6412.237"},{"key":"bibr14-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90323-4"},{"key":"bibr15-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197506000-00021"},{"key":"bibr16-000456328502200303","unstructured":"Leslie S: Continus continuous release preparations. Brit J Clin Pract 1981; Suppl 10: 12\u201314."},{"key":"bibr17-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1177\/000456328402100415"},{"key":"bibr18-000456328502200303","first-page":"9","volume":"58","author":"Welsh J","year":"1983","journal-title":"Roy Soc Med (Int Cong Symp Ser)"},{"key":"bibr19-000456328502200303","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.214"},{"key":"bibr20-000456328502200303","unstructured":"Sawe J. Oral morphine and methadone in the treatment of cancer pain. 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