{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:15:13Z","timestamp":1777425313712,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1985,11,1]],"date-time":"1985-11-01T00:00:00Z","timestamp":499651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:p>The diagnostic usefulness of fasting total serum bile acids (SBA\/F) in the detection of liver diseases and assessment of different aspects of hepatic function alteration was evaluated in 61 healthy subjects and 186 patients with liver disease. The value of SBA\/F was compared with other routine tests. In 49 healthy subjects and 92 patients, serum bile acids were also measured after the im administration of Ceruletide as a cholecystokinetic agent (SBA\/C).<\/jats:p>\n                  <jats:p>The diagnostic efficacy for the detection of disease states was better with aspartate-aminotransferase (EC 2.6.1.1) and alanine-aminotransferase (EC 2.6.1.2) than with SBA\/F. When SBA\/C was also determined the diagnostic efficacy was not substantially better than the SBA\/F test.<\/jats:p>\n                  <jats:p>In the assessment of hepatocellular necrosis SBA\/F showed a higher rate of misclassification errors compared to alanine-aminotransferase (mean error 45% vs 17%), whereas SBA\/F gave similar results with direct bilirubin and pseudocholinesterase (EC 3.1.1.8) in the evaluation of cholestasis (mean error 40% vs 41%) and impaired biosynthesis (mean error 39% vs 40%), respectively.<\/jats:p>\n                  <jats:p>Serum bile acid determination did not show any significant diagnostic advantage with respect to the other routine liver tests.<\/jats:p>","DOI":"10.1177\/000456328502200608","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"596-605","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of the Diagnostic Value of Serum Bile Acid in the Detection and Functional Assessment of Liver Diseases"],"prefix":"10.1177","volume":"22","author":[{"given":"C","family":"Cravetto","sequence":"first","affiliation":[{"name":"D.E.A. Ospedale \u2018Le Molinette\u2019, Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Molino","sequence":"additional","affiliation":[{"name":"Clinica Medica A, Universit\u00e0 di Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Biondi","sequence":"additional","affiliation":[{"name":"Clinica Medica A, Universit\u00e0 di Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Cavanna","sequence":"additional","affiliation":[{"name":"Patologia Medica A, Universit\u00e0 di Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Avagnina","sequence":"additional","affiliation":[{"name":"Patologia Medica D, Universit\u00e0 di Torino"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Frediani","sequence":"additional","affiliation":[{"name":"Centre Elaborazione Numerate dei Segnali (C.E.N.S.), C.N.R. 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