{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:15:35Z","timestamp":1777425335790,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1986,1,1]],"date-time":"1986-01-01T00:00:00Z","timestamp":504921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1986,1]]},"abstract":"\n Two patients with familial dysalbuminaemic hyperthyroxinaemia (FDH) are described in whom the albumin variant resulted in raised total T\n 4<\/jats:sub>\n levels, and artefactually raised free T\n 4<\/jats:sub>\n using a \u2018single-step\u2019 technique employing an analogue of T\n 4<\/jats:sub>\n as tracer. The first patient was clinically euthyroid and presented with relapse of schizophrenia and abnormal thyroid function tests (total T\n 4<\/jats:sub>\n 336 nmol\/L, total T\n 3<\/jats:sub>\n 4\u00b72 nmol\/L, TSH 1\u00b78 mU\/L, free T\n 4<\/jats:sub>\n 73 pmol\/L). These results led to diagnostic confusion and the patient was treated with a short course of anti-thyroid drugs. The second patient had signs and symptoms of thyrotoxicosis at her first visit but was clinically euthyroid 5 months later when she was 10 weeks pregnant. Thyroid function tests were total T\n 4<\/jats:sub>\n 259 nmol\/L, total T\n 3<\/jats:sub>\n 3\u00b76 nmol\/L, TSH 3\u00b78 mU\/L, free T\n 4<\/jats:sub>\n 46 pmol\/L. Further studies showed both patients to be biochemically euthyroid. A variant albumin was confirmed in both patients by a screening test for FDH and by reverse-flow electrophoresis. Family studies on 10 relatives of the first patient identified eight with FDH. A simple screening procedure for the indentification of FDH is described and the use of laboratory tests in suspected cases is discussed.\n <\/jats:p>","DOI":"10.1177\/000456328602300107","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"59-64","source":"Crossref","is-referenced-by-count":11,"title":["Thyroid Function Tests in Patients with Familial Dysalbuminaemic Hyperthyroxinaemia (FDH)"],"prefix":"10.1177","volume":"23","author":[{"given":"M Felicity","family":"Stewart","sequence":"first","affiliation":[{"name":"University of Manchester, Department of Chemical Pathology, Hope Hospital, Eccles Old Road, Salford M6 8HD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy A","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"University of Manchester, Department of Chemical Pathology, Hope Hospital, Eccles Old Road, Salford M6 8HD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of Manchester, Department of Chemical Pathology, Hope Hospital, Eccles Old Road, Salford M6 8HD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,1,1]]},"reference":[{"key":"bibr1-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-53-2-353"},{"key":"bibr2-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/30.7.1179"},{"key":"bibr3-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-55-2-244"},{"key":"bibr4-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1983.tb02991.x"},{"key":"bibr5-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/29.7.1408"},{"key":"bibr6-000456328602300107","first-page":"597","volume-title":"Thyroid Research","author":"Ekins RP","year":"1976"},{"key":"bibr7-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1983.tb03181.x"},{"key":"bibr8-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1007\/BF03348351"},{"key":"bibr9-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1981.tb00670.x"},{"key":"bibr10-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90922-6"},{"key":"bibr11-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03300030026015"},{"key":"bibr12-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1210\/endo-101-4-1228"},{"key":"bibr13-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(81)90089-5"},{"key":"bibr14-000456328602300107","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-3-499"},{"key":"bibr15-000456328602300107","unstructured":"Stockigt JR, Stevens V, Dyer S, Diagnosis of plasma binding abnormalities in euthyroid hyperthyroxinemia. Proceedings of the 7th International Congress of Endocrinology 1984; Abst 2462."}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328602300107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328602300107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:29:05Z","timestamp":1777375745000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456328602300107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1177\/000456328602300107"],"URL":"https:\/\/doi.org\/10.1177\/000456328602300107","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}