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Dopamine-blocking activity, measured in serum samples from schizophrenic patients receiving chlorpromazine, was 1\u00b785\u20139\u00b71 times higher than serum chlorpromazine level measured by HPLC. The correlation between the two methods was 0\u00b775. Dopamine-blocking activity was related more closely to dose of drug and to serum prolactin level than was serum chlorpromazine level measured by HPLC.<\/jats:p>","DOI":"10.1177\/000456328602300316","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"340-345","source":"Crossref","is-referenced-by-count":3,"title":["Determination of Chlorpromazine in Serum by Radioreceptor Assay and HPLC"],"prefix":"10.1177","volume":"23","author":[{"given":"J","family":"Krska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Addison","sequence":"additional","affiliation":[{"name":"Royal Manchester Children's Hospital, Pendlebury, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S D","family":"Soni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,5,1]]},"reference":[{"key":"bibr1-000456328602300316","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.137.12.1518"},{"key":"bibr2-000456328602300316","doi-asserted-by":"publisher","DOI":"10.1038\/270180a0"},{"key":"bibr3-000456328602300316","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1976.01770030003001"},{"key":"bibr4-000456328602300316","doi-asserted-by":"publisher","DOI":"10.1021\/ac00230a007"},{"key":"bibr5-000456328602300316","unstructured":"Krska J, Sampath G, Shah A, Soni SD. 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