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This paper reports an investigation of the pharmacokinetics of a sub-therapeutic oral dose of rifampicin in healthy subjects, in patients with cirrhosis and in subjects with Gilbert's syndrome. The areas under the plasma concentration curves (AUC) in patients with cirrhosis were significantly greater than in healthy subjects. Subjects with Gilbert's syndrome had decreased AUCs compared with healthy subjects and were clearly distinguished from patients with cirrhosis. Rifampicin concentration in serum was measured by HPLC using a novel direct injection technique.<\/jats:p>","DOI":"10.1177\/000456328702400105","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"36-40","source":"Crossref","is-referenced-by-count":3,"title":["Drugs as Probes of Organ Function: Evaluation of the Hepatobiliary Axis Using Oral Rifampicin and Novel High Performance Liquid Chromatography"],"prefix":"10.1177","volume":"24","author":[{"given":"J D","family":"Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ruddock","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Sandwell District General Hospital, West Bromwich, West Midlands B71 4HJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A C","family":"Allen-Narker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dudley Road Hospital, Birmingham B18 7QH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G V H","family":"Bradby","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dudley Road Hospital, Birmingham B18 7QH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dudley Road Hospital, Birmingham B18 7QH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B M","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,1,1]]},"reference":[{"key":"bibr1-000456328702400105","first-page":"17","volume-title":"Diagnostic Procedures in the Evaluation of Hepatic Diseases","author":"Tygstrup N","year":"1983"},{"key":"bibr2-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1925.02660410020008"},{"key":"bibr3-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1967.03120160102016"},{"key":"bibr4-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197506052922302"},{"key":"bibr5-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1136\/gut.18.9.697"},{"key":"bibr6-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1983.tb00126.x"},{"key":"bibr7-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1983.tb00125.x"},{"key":"bibr8-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)80804-X"},{"key":"bibr9-000456328702400105","doi-asserted-by":"publisher","DOI":"10.3109\/00365528109182033"},{"key":"bibr10-000456328702400105","first-page":"114","volume":"57","author":"Kajser L","year":"1979","journal-title":"Med Biol"},{"key":"bibr11-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196906052802303"},{"key":"bibr12-000456328702400105","first-page":"245","volume":"27","author":"Billing BH","year":"1964","journal-title":"Clin Sci"},{"key":"bibr13-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92226-7"},{"key":"bibr14-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90126-3"},{"key":"bibr15-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308307"},{"key":"bibr16-000456328702400105","doi-asserted-by":"publisher","DOI":"10.1007\/BF00586591"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328702400105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328702400105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:29:27Z","timestamp":1777375767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456328702400105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1177\/000456328702400105"],"URL":"https:\/\/doi.org\/10.1177\/000456328702400105","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}