{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:20:38Z","timestamp":1777425638704,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1987,11,1]],"date-time":"1987-11-01T00:00:00Z","timestamp":562723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:p>\n                    A sensitive radioimmunoassay for human parathyroid hormone (hPTH) to diagnose hypoparathyroid conditions is described. The antiserum was raised in goats against extracted hPTH. Synthetic human PTH fragment (53\u201384) is used as a standard and\n                    <jats:sup>125<\/jats:sup>\n                    I-Tyr\n                    <jats:sup>52<\/jats:sup>\n                    hPTH (53\u201384) as a tracer. After a two-step incubation (24 h+24 h) at 4\u00b0C, the bound and free fractions are separated by a mixture of second antibody and polyethylene glycol solution. The detection limit for hPTH (53\u201384) is 2 pmol\/L hPTH (53\u201384) (2 mol\/tube). The PTH level in 36 healthy subjects was 5\u201312 pmol\/L. Of 14 patients with hypoparathyroidism 11 patients had PTH concentrations below normal, two patients had levels on the lower limit of the normal range (5 pmol\/L). The concentration of one patient with pseudohypoparathyroidism was markedly elevated. This assay is suitable for detecting low PTH levels and for studying changes of PTH concentration within the normal range.\n                  <\/jats:p>","DOI":"10.1177\/000456328702400610","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"608-613","source":"Crossref","is-referenced-by-count":5,"title":["Sensitive Homologous Radioimmunoassay for Human Parathyroid Hormone to Diagnose Hypoparathyroid Conditions"],"prefix":"10.1177","volume":"24","author":[{"given":"D","family":"Zillikens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F P","family":"Armbruster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Schmidt-Gayk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Raue","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Endokrinologie der Universit\u00e4t Heidelberg, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,11,1]]},"reference":[{"key":"bibr1-000456328702400610","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1542\/peds.71.1.64","volume":"71","author":"Mallette LE","year":"1983","journal-title":"Pediatrics"},{"key":"bibr2-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-5-1017"},{"key":"bibr3-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1981.tb00686.x"},{"key":"bibr4-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1980.tb01023.x"},{"key":"bibr5-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1095781"},{"key":"bibr6-000456328702400610","first-page":"789","volume":"18","author":"Wood WG","year":"1980","journal-title":"J Clin Chem Clin Biochem"},{"key":"bibr7-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1986.tb01640.x"},{"key":"bibr8-000456328702400610","unstructured":"Zillikens D, Armbruster FP, Hitzler W, Schneller homologer Radioimmunoassay f\u00fcr human-Parathormon (hPTH) zur Differenzierung der hyperkalz\u00e4mischen Kxise&AUrztl Lab. 1985; 31: 151\u20136."},{"key":"bibr9-000456328702400610","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/clinchem\/32.1.57","volume":"32","author":"Schmidt-Gayk H","year":"1986","journal-title":"Clin Chem"},{"key":"bibr10-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1038\/194495a0"},{"key":"bibr11-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/28.8.1749"},{"key":"bibr12-000456328702400610","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/clinchem\/19.7.699","volume":"19","author":"Zettner A","year":"1973","journal-title":"Clin Chem"},{"key":"bibr13-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109794"},{"key":"bibr14-000456328702400610","first-page":"381","volume":"4","author":"Allgrove J","year":"1986","journal-title":"J Immunoassay"},{"key":"bibr15-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/32.3.418"},{"key":"bibr16-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-5-1007"},{"key":"bibr17-000456328702400610","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-2-447"},{"key":"bibr18-000456328702400610","first-page":"479","volume":"22","author":"Fogh-Andersen N","year":"1984","journal-title":"J Clin Chem Clin Biochem"},{"key":"bibr19-000456328702400610","first-page":"309","volume":"99","author":"Slatopolsky E","year":"1982","journal-title":"J Lab Clin Med"},{"key":"bibr20-000456328702400610","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/clinchem\/28.1.87","volume":"28","author":"Gorog RH","year":"1982","journal-title":"Clin Chem"},{"key":"bibr21-000456328702400610","first-page":"138","volume":"246","author":"Atkinson MJ","year":"1982","journal-title":"Acta Endocrinol"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328702400610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328702400610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:29:45Z","timestamp":1777375785000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456328702400610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1987,11]]}},"alternative-id":["10.1177\/000456328702400610"],"URL":"https:\/\/doi.org\/10.1177\/000456328702400610","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}