{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:02:37Z","timestamp":1777428157363,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1988,7,1]],"date-time":"1988-07-01T00:00:00Z","timestamp":583718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:p>We describe a MUMPS program to facilitate the evaluation of the diagnostic effectiveness and efficiency of laboratory tests using receiver operating characteristic (ROC) curves and likelihood ratios (LR). Test results from a population with and without a disease are stored into retrievable, editable data bases. Either single or a combination (\u22649) of different test data files can be accessed to generate tables of calculated frequency distribution, sensitivity, 1-specificity and LR at variable decision thresholds. The program also calculates the area under the ROC curve, confidence intervals and SE. The selection of the optimum cut-off value is assisted by graphical plots of frequency distribution, ROC and decision level curves as illustrated by using some \u2018cardiac\u2019 enzyme tests.<\/jats:p>","DOI":"10.1177\/000456328802500416","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"411-416","source":"Crossref","is-referenced-by-count":19,"title":["A Computer Program for Rapid Generation of Receiver Operating Characteristic Curves and Likelihood Ratios in the Evaluation of Diagnostic Tests"],"prefix":"10.1177","volume":"25","author":[{"given":"Thomas G","family":"Pellar","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, University Hospital (University of Western Ontario), London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred Y","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University Hospital (University of Western Ontario), London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Ralph","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, University Hospital (University of Western Ontario), London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,7,1]]},"reference":[{"key":"bibr1-000456328802500416","doi-asserted-by":"publisher","DOI":"10.2307\/4586294"},{"key":"bibr2-000456328802500416","volume-title":"Beyond Normality: the Predictive Value and Efficiency of Medical Diagnosis.","author":"Galen RS","year":"1975"},{"key":"bibr3-000456328802500416","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/27.9.1569"},{"key":"bibr4-000456328802500416","first-page":"13","volume":"110","author":"Beck JR","year":"1986","journal-title":"Arch Pathol Lab 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Diagnosis and the laboratory: Logical Strategies for Common Medical Problems.","author":"Suchman AL","year":"1986"},{"key":"bibr18-000456328802500416","first-page":"952","volume":"110","author":"Abendroth TW","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"bibr19-000456328802500416","volume-title":"Predicitive Value Calculator.","author":"Galen RS","year":"1985"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328802500416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456328802500416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:35:16Z","timestamp":1777376116000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456328802500416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1177\/000456328802500416"],"URL":"https:\/\/doi.org\/10.1177\/000456328802500416","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}