{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:42:36Z","timestamp":1782276156386,"version":"3.54.5"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1989,5,1]],"date-time":"1989-05-01T00:00:00Z","timestamp":609984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:p>An assay for the measurement of 18-hydroxycorticosterone (18-OHB) in plasma has been validated. The method involves extraction of plasma with dichloro-methane, thin layer chromatography and radioimmunoassay with an iodinated 18-hydroxycorticosterone-3-carboxymethyloxime ligand. The plasma concentration of 18-OHB was measured in 16 patients with primary hyperaldosteronism and 20 control subjects. After overnight recumbency a significantly higher mean concentration of 18-OHB was found in the samples taken from the patients than in those from the control subjects. The degree of elevation did not clearly discriminate between patients with a unilateral adenoma and those with bilateral adrenal hyperplasia. A significant anomalous postural decrease in the 18-OHB concentration occurred in 10 of the 13 patients with an adenoma, whereas there was a significant postural increase in the three patients with hyperplasia.<\/jats:p>","DOI":"10.1177\/000456328902600303","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:57:08Z","timestamp":1391619428000},"page":"227-232","source":"Crossref","is-referenced-by-count":8,"title":["18-Hydroxycorticosterone as a Marker for Primary Hyperaldosteronism"],"prefix":"10.1177","volume":"26","author":[{"given":"Ruth","family":"Lapworth","sequence":"first","affiliation":[{"name":"Supraregional Assay Laboratory, Department of Chemical Pathology, St Mary's Hospital, London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Short","sequence":"additional","affiliation":[{"name":"Supraregional Assay Laboratory, Department of Chemical Pathology, St Mary's Hospital, London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V H T","family":"James","sequence":"additional","affiliation":[{"name":"Supraregional Assay Laboratory, Department of Chemical Pathology, St Mary's Hospital, London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1989,5,1]]},"reference":[{"key":"bibr1-000456328902600303","first-page":"6","volume":"45","author":"Conn JW","year":"1955","journal-title":"J Lab Clin Med"},{"key":"bibr2-000456328902600303","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6035.554"},{"key":"bibr3-000456328902600303","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(85)80069-4"},{"key":"bibr4-000456328902600303","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-1-87"},{"key":"bibr5-000456328902600303","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-60-1-67"},{"key":"bibr6-000456328902600303","doi-asserted-by":"publisher","DOI":"10.1159\/000179892"},{"key":"bibr7-000456328902600303","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-43-1-92"},{"key":"bibr8-000456328902600303","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(85)80081-5"},{"key":"bibr9-000456328902600303","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(78)90161-9"},{"key":"bibr10-000456328902600303","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(88)90186-0"},{"key":"bibr11-000456328902600303","first-page":"xlvii","volume":"57","author":"Nars PW","year":"1973","journal-title":"J Endocrinol"},{"key":"bibr12-000456328902600303","unstructured":"Wilkins TA, Chadney DC, Bryant J,  In \u2018Radioimmunoassay and related procedures in Medicine\u2019 1977; 1: 399\u2013423. 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