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Five min after injection IR \u03b1-ANP levels had nearly doubled in response to both doses of morphine. At 10 min, plasma IR \u03b1-ANP concentrations were lower than at 5 min in the 0\u00b715 mg\/kg group suggesting that IR \u03b1-ANP levels peak shortly after morphine administration. Morphine has been widely used in the treatment of acute left ventricular failure and ANP is a recently discovered hormone which possesses unique favourable effects in patients with congestive heart failure when administered exogenously. The combination of these data suggests an important potential role for ANP in the mechanism of action of morphine in the treatment of acute left ventricular failure.<\/jats:p>","DOI":"10.1177\/000456329002700105","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"21-24","source":"Crossref","is-referenced-by-count":5,"title":["Morphine Increases Plasma Immunoreactive Atrial Natriuretic Peptide Levels in Humans"],"prefix":"10.1177","volume":"27","author":[{"given":"\u00c7","family":"\u00d6\u011f\u00fctman","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"\u00d6zben","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, 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