{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:05:36Z","timestamp":1777428336310,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>Circulating immunoreactive intact human parathyroid hormone (PTH) was measured by a direct immunoradiometric assay (IRMA) and the results compared with a radio-immunoassay (RIA) which required extraction and concentration prior to assay. The sensitivity of the IRMA was better than that of the RIA (0\u00b76 vs 2\u00b70 pmol\/L). In control subjects the hPTH concentrations ranged between 0\u00b76 and 6\u00b77 pmol\/L and in patients with hypercalcaemia due to malignant diseases, sarcoidosis and hypoparathyroidism none could be detected. In patients with primary hyperparathyroidism the concentrations ranged from 5\u00b72 to 27\u00b70 pmol\/L. In patients with renal osteodystrophy serum human PTH concentrations ranged from 7\u00b76 to 285 and in those with chronic renal failure but without evidence of renal osteodystrophy from 0\u00b75 to 5\u00b72 pmol\/L. The major advantages of the IRMA are its much simpler performance and its higher sensitivity which makes studies of the physiology of PTH secretion in humans possible.<\/jats:p>","DOI":"10.1177\/000456329002700114","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"69-72","source":"Crossref","is-referenced-by-count":22,"title":["Immunoradiometric Assay for Intact Human Parathyroid Hormone: Characteristics, Clinical Application and Comparison with a Radio-Immunoassay"],"prefix":"10.1177","volume":"27","author":[{"given":"M.","family":"Fr\u00f6lich","sequence":"first","affiliation":[{"name":"Department of Endocrinology (LI Q49), University Hospital, 2333 AA Leiden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S T","family":"Walma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (LI Q49), University Hospital, 2333 AA Leiden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Paulson","sequence":"additional","affiliation":[{"name":"Incstar, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S E","family":"Papapoulos","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (LI Q49), University Hospital, 2333 AA Leiden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"key":"bibr1-000456329002700114","doi-asserted-by":"publisher","DOI":"10.1177\/000456328602300408"},{"key":"bibr2-000456329002700114","doi-asserted-by":"publisher","DOI":"10.1177\/000456328602300409"},{"key":"bibr3-000456329002700114","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-2-447"},{"key":"bibr4-000456329002700114","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.8.1364"},{"key":"bibr5-000456329002700114","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.2.407"},{"key":"bibr6-000456329002700114","first-page":"10","volume":"31","author":"Kruseman Nieuwenhuijzen AC","year":"1987","journal-title":"Neth J Med"},{"key":"bibr7-000456329002700114","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.5.989a"},{"key":"bibr8-000456329002700114","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-5-1007"},{"key":"bibr9-000456329002700114","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.8.1376"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329002700114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329002700114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:35:58Z","timestamp":1777376158000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456329002700114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1177\/000456329002700114"],"URL":"https:\/\/doi.org\/10.1177\/000456329002700114","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}