{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:09:30Z","timestamp":1777428570613,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:p>Serum ferritin, prealbumin, pseudocholinesterase, \u03b1-1-antitrypsin and caeruloplasmin were determined in control subjects and patients with pancreatic cancer, chronic pancreatitis or extra-pancreatic disease mainly of gastrointestinal origin, in order to investigate the different hepatic changes which influence serum ferritin in chronic pancreatic and other digestive diseases. Increased circulating ferritin was found in pancreatic cancer and extra-pancreatic disease when compared to controls.<\/jats:p>\n                  <jats:p>Correlations were detected between ferritin and the other proteins investigated and between ferritin and total bilirubin, alkaline phosphatase and alanine aminotransferase. Multiple regression analysis demonstrated that cholestasis accounts for 45% of circulating ferritin, the acute-phase response accounted for 18% and decreased liver function accounted for 11%. We conclude that the increase in serum ferritin in chronic pancreatic and other gastrointestinal diseases largely depends on liver changes, with cholestasis probably playing a primary role.<\/jats:p>","DOI":"10.1177\/000456329102800105","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"34-38","source":"Crossref","is-referenced-by-count":13,"title":["Hepatic Changes and Serum Ferritin in Pancreatic Cancer and other Gastrointestinal Diseases: The Role of Cholestasis"],"prefix":"10.1177","volume":"28","author":[{"given":"Daniela","family":"Basso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Fabris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Del Favero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Meggiato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Piera","family":"Panozzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Vianello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Plebani","sequence":"additional","affiliation":[{"name":"Cattedra di Biochimica Clinica (Laboratorio di Analisi), Universit\u00e0 degli Studi di Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remo","family":"Naccarato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,1,1]]},"reference":[{"key":"bibr1-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1042\/cs0700215"},{"key":"bibr2-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197505012921805"},{"key":"bibr3-000456329102800105","first-page":"288","volume":"140","author":"Pr\u00e9 J","year":"1989","journal-title":"Ann Med Interne"},{"key":"bibr4-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1042\/bj1990565"},{"key":"bibr5-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.4.827.827"},{"key":"bibr6-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.tb01226.x"},{"key":"bibr7-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)32470-0"},{"key":"bibr8-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1973.26"},{"key":"bibr9-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb25443.x"},{"key":"bibr10-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1976.164"},{"key":"bibr11-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1159\/000198842"},{"key":"bibr12-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1159\/000225861"},{"key":"bibr13-000456329102800105","first-page":"146","volume":"32","author":"Fabris C","year":"1985","journal-title":"Hepatogastroenterology"},{"key":"bibr14-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1007\/BF01311703"},{"key":"bibr15-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1159\/000199114"},{"key":"bibr16-000456329102800105","first-page":"276","volume":"32","author":"Simonetti RG","year":"1985","journal-title":"Hepatogastroenterology"},{"key":"bibr17-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(75)80092-8"},{"key":"bibr18-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1984.12005680"},{"key":"bibr19-000456329102800105","first-page":"241","volume":"13","author":"Cubilla AL","year":"1978","journal-title":"Phatol Annu"},{"key":"bibr20-000456329102800105","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(65)90004-2"},{"key":"bibr21-000456329102800105","volume-title":"Automation in Analytical Chemistry: Technicon Symposia. 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