{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:15:58Z","timestamp":1777428958101,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>\n                    A relationship between serum concentrations of ionized calcium and parathyroid hormone (PTH) in persons without parathyroid overactivity was defined by performing an oral calcium load test. As a result, a serum PTH concentration greater than 2\u00b76 pmol\/L in a hypercalcaemic patient was regarded as suggestive of hyperparathyroidism. Fasting serum PTH concentrations in 58 patients with surgically and histologically proven primary hyperparathyroidism (PHPT) were all above 2\u00b77 pmol\/L (range 3\u00b72\u201384\u00b75). Thirteen of 20 patients with familial benign hypercalcaemia (FBH) had fasting serum PTH concentrations greater than 2\u00b76 pmol\/L (range 1\u00b76\u20136\u00b71). There was a significant correlation between serum PTH and age in the FBH patients only. Fasting urine calcium excretion (Ca\n                    <jats:sub>E<\/jats:sub>\n                    ) ranged from 14 to 222 \u03bcmol\/L of glomerular filtrate in PHPT and 3\u201334 \u03bcmol\/L of glomerular filtrate in FBH. The best biochemical discriminant between patients with PHPT and FBH was a plot of fasting serum PTH against Ca\n                    <jats:sub>E<\/jats:sub>\n                    . A plot of post-calcium load PTH against post-load Ca\n                    <jats:sub>E<\/jats:sub>\n                    showed no further significant advantage in discriminating between the two conditions.\n                  <\/jats:p>","DOI":"10.1177\/000456329202900107","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"52-58","source":"Crossref","is-referenced-by-count":41,"title":["Urine Calcium and Serum Ionized Calcium, Total Calcium and Parathyroid Hormone Concentrations in the Diagnosis of Primary Hyperparathyroidism and Familial Benign Hypercalcaemia"],"prefix":"10.1177","volume":"29","author":[{"given":"Ian R","family":"Gunn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Surgery, Law Hospital, Carluke ML8 5ER, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,1,1]]},"reference":[{"key":"bibr1-000456329202900107","first-page":"79","volume":"67","author":"Thomas JM","year":"1985","journal-title":"Ann R Coll Surg Engl"},{"key":"bibr2-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6628.1016-a"},{"key":"bibr3-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.8.1364"},{"key":"bibr4-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1177\/000456329102800207"},{"key":"bibr5-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30362-1"},{"key":"bibr6-000456329202900107","doi-asserted-by":"crossref","first-page":"suppl","DOI":"10.1177\/000456328802500521","volume":"25","author":"Evans RM","year":"1988","journal-title":"Ann Clin Biochem"},{"key":"bibr7-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-3-541"},{"key":"bibr8-000456329202900107","first-page":"217","volume-title":"Clinical Endocrinology","volume":"2","author":"Marx SJ","year":"1982"},{"key":"bibr9-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-50-5-862"},{"key":"bibr10-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.3.294"},{"key":"bibr11-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1990.tb03881.x"},{"key":"bibr12-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80536-7"},{"key":"bibr13-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1987.tb01182.x"},{"key":"bibr14-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1976.tb08246.x"},{"key":"bibr15-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6719.210"},{"key":"bibr16-000456329202900107","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1990.tb00888.x"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329202900107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329202900107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:37:14Z","timestamp":1777376234000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456329202900107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1177\/000456329202900107"],"URL":"https:\/\/doi.org\/10.1177\/000456329202900107","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}