{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:16:47Z","timestamp":1777457807830,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>Concentrations of serum and plasma von Willebrand factor antigen were measured in over 200 patients with a variety of connective tissue diseases, and in control samples from over 200 asymptomatic individuals. This comprehensive study found the highest concentrations of von Willebrand factor antigen in patients with vasculitis, Sj\u00f6gren's syndrome, Felty's syndrome, giant cell arteritis and polyarteritis nodosum. Raised values were also found in rheumatoid arthritis, systemic lupus erythematosus, polymyalgia rheumatica, systemic sclerosis, Raynaud's syndrome, Takayasu's arteritis and Wegener's granulomatosis, but not in oesteoarthritis. It is possible that the difference in von Willebrand factor antigen concentrations in two sub-groups of systemic necrotising arteritis (Wegener's granulomatosis and polyarteritis nodosum) may imply different disease processes. The large numbers involved have allowed us to confirm or question smaller studies of the role of this molecule in connective tissue disease.<\/jats:p>","DOI":"10.1177\/000456329202900110","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"67-71","source":"Crossref","is-referenced-by-count":28,"title":["Plasma and Serum Von Willebrand Factor Antigen Concentrations in Connective Tissue Disorders"],"prefix":"10.1177","volume":"29","author":[{"given":"A D","family":"Blann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Winkles","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Selly Oak Hospital, Raddlebarn Road, Birmingham B29, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Wainwright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,1,1]]},"reference":[{"key":"bibr1-000456329202900110","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-4-482"},{"key":"bibr2-000456329202900110","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-3-311"},{"key":"bibr3-000456329202900110","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92650-1"},{"key":"bibr4-000456329202900110","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.6.441"},{"key":"bibr5-000456329202900110","first-page":"1404","volume":"12","author":"Nusinow SR","year":"1986","journal-title":"Arthritis Rheum"},{"key":"bibr6-000456329202900110","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270462"},{"key":"bibr7-000456329202900110","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/29.1.6"},{"key":"bibr8-000456329202900110","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/27.4.281"},{"key":"bibr9-000456329202900110","first-page":"630","volume":"39","author":"Brinkhous KM","year":"1980","journal-title":"Fed Proc"},{"key":"bibr10-000456329202900110","first-page":"879","volume":"2","author":"Pannekoek H","year":"1989","journal-title":"Clin Haem"},{"key":"bibr11-000456329202900110","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1647029"},{"key":"bibr12-000456329202900110","first-page":"351","volume":"39","author":"Short PE","year":"1982","journal-title":"Med Lab Sci"},{"key":"bibr13-000456329202900110","first-page":"55","volume":"8","author":"Olsson A","year":"1990","journal-title":"Clin Exp Rheumatol"},{"key":"bibr14-000456329202900110","doi-asserted-by":"publisher","DOI":"10.3109\/03009748809098813"},{"key":"bibr15-000456329202900110","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60869-6"},{"key":"bibr16-000456329202900110","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270912"},{"key":"bibr17-000456329202900110","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.06.110190.001245"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329202900110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329202900110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:37:14Z","timestamp":1777376234000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456329202900110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1177\/000456329202900110"],"URL":"https:\/\/doi.org\/10.1177\/000456329202900110","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}