{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:18:42Z","timestamp":1777429122783,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:p>We have investigated the influence of variation of the concentrations of serum albumin and immunoglobulins on serum fructosamine concentration in 33 patients with nephrotic syndrome, and 18 patients with cirrhosis of the liver. Protein alterations were evident in these patients and they were compared with 109 normal subjects, 43 patients with type II diabetes mellitus and nine diabetic patients with nephrotic syndrome.<\/jats:p>\n                  <jats:p>The mean serum fructosamine concentration in diabetic patients (2\u00b776\u00b10\u00b753 mmol\/L) was significantly increased ( P &lt; 0\u00b7001) by comparison with normal subjects (1\u00b793 \u00b10\u00b720 mmol\/L) and the other patients studied. Patients with diabetic nephropathy had higher ( P &lt; 0\u00b701) serum fructosamine concentrations (2\u00b723\u00b1 0\u00b754 mmol\/L) than non-diabetic patients with the nephrotic syndrome (1\u00b757 \u00b1 0\u00b737 mmol\/L) but remained with the normal range. Positive correlations were observed between fructosamine and immunoglobulins G and M in nephrotic and cirrhotic patients. Serum immunoglobulin A was also directly correlated with serum fructosamine in patients with cirrhosis of the liver. An inverse correlation between albumin and fructosamine in serum of patients with cirrhosis of the liver was also noted. We conclude that the fructosamine assay is not useful in the assessment of glycemic control in patients with cirrhosis of the liver, nephrotic syndrome or in any other clinical situation in which protein metabolism is altered.<\/jats:p>","DOI":"10.1177\/000456329202900412","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"437-442","source":"Crossref","is-referenced-by-count":28,"title":["Serum Fructosamine Concentration in Patients with Nephrotic Syndrome and with Cirrhosis of the Liver: The Influence of Hypoalbuminaemia and Hypergammaglobulinaemia"],"prefix":"10.1177","volume":"29","author":[{"given":"C","family":"Constanti","sequence":"first","affiliation":[{"name":"Centre de Recerca Biom\u00e8dica, Hospital de Sant Joan, C\/Sant Joan s\/n, 43201, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Simo","sequence":"additional","affiliation":[{"name":"Centre de Recerca Biom\u00e8dica, Hospital de Sant Joan, C\/Sant Joan s\/n, 43201, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Joven","sequence":"additional","affiliation":[{"name":"Centre de Recerca Biom\u00e8dica, Hospital de Sant Joan, C\/Sant Joan s\/n, 43201, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Camps","sequence":"additional","affiliation":[{"name":"Centre de Recerca Biom\u00e8dica, Hospital de Sant Joan, C\/Sant Joan s\/n, 43201, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"bibr1-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.12.2153"},{"key":"bibr2-000456329202900412","first-page":"B37","volume":"32","author":"Vlassara H","year":"1986","journal-title":"Clin Chem"},{"key":"bibr3-000456329202900412","first-page":"B64","volume":"32","author":"Goldstein DE","year":"1986","journal-title":"Clin Chem"},{"key":"bibr4-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(83)90078-5"},{"key":"bibr5-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/31.9.1550"},{"key":"bibr6-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.2.269"},{"key":"bibr7-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/31.12.2005"},{"key":"bibr8-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/36.1.136"},{"key":"bibr9-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6396.863"},{"key":"bibr10-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/32.8.1610"},{"key":"bibr11-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/35.1.134"},{"key":"bibr12-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(89)90071-5"},{"key":"bibr13-000456329202900412","first-page":"357","volume":"8","author":"Arderiu X Fuentes","year":"1989","journal-title":"Qu\u00edm Clin"},{"key":"bibr14-000456329202900412","first-page":"329","volume":"8","author":"Sim\u00f3 JM","year":"1989","journal-title":"Quim Clin"},{"key":"bibr15-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/36.2.409a"},{"key":"bibr16-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/32.2.368"},{"key":"bibr17-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.7.1141"},{"key":"bibr18-000456329202900412","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.12.2444"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329202900412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329202900412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:37:36Z","timestamp":1777376256000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456329202900412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1177\/000456329202900412"],"URL":"https:\/\/doi.org\/10.1177\/000456329202900412","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}