{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:00:08Z","timestamp":1790352008359,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>The 9697 electrophoretograms performed over an 8 year period were reviewed to identify the frequency and clinical associations of the finding of a prominent transthyretin band in serum or urine, the concentration of which was equal to or greater than a 64 mg\/dL protein calibrator. All samples were electrophoresed at a constant 90 V using agarose gels with a barbital buffer pH 8\u00b76 and Ponceau S staining. Reference calibrators were used as standards to identify increased transthyretin bands and the patients' clinical records were subsequently reviewed.<\/jats:p>\n                  <jats:p>High values were found in 46 patients' sera and a further nine patients' urines representing 0\u00b757% of the total workload. Renal impairment was present in 58% of cases including those with chronic renal failure, the nephrotic syndrome and paraproteinaemia. The high levels were not persistent in three myeloma cases where there was a recovery in renal function following chemotherapy. In some nephrotics, a high urine transthyretin may be secondary to a general hepatic albumin and transport protein synthesis response to severe proteinuria. Why the serum transthyretin was elevated in many other cases remains unclear.<\/jats:p>","DOI":"10.1177\/000456329303000604","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"550-554","source":"Crossref","is-referenced-by-count":15,"title":["Clinical Associations of an Increased Transthyretin Band in Routine Serum and Urine Protein Electrophoresis"],"prefix":"10.1177","volume":"30","author":[{"given":"W P","family":"Tormey","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, Beaumont Hospital, Dublin 9, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Beaumont Hospital, Dublin 9, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1993,11,1]]},"reference":[{"key":"bibr1-000456329303000604","doi-asserted-by":"publisher","DOI":"10.1177\/000456328702400202"},{"key":"bibr2-000456329303000604","doi-asserted-by":"publisher","DOI":"10.1177\/000456329102800310"},{"key":"bibr3-000456329303000604","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(75)90379-4"},{"key":"bibr4-000456329303000604","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90241-1"},{"key":"bibr5-000456329303000604","doi-asserted-by":"publisher","DOI":"10.1177\/31.5.6341455"},{"key":"bibr6-000456329303000604","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(87)90265-6"},{"key":"bibr7-000456329303000604","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/30.11.1887"},{"key":"bibr8-000456329303000604","first-page":"363","volume-title":"The Metabolic and Molecular Basis of Acquired Disease","author":"Woo P","year":"1990"},{"key":"bibr9-000456329303000604","first-page":"519","volume-title":"Textbook of Clinical Chemistry","author":"Silverman LM","year":"1986"},{"key":"bibr10-000456329303000604","unstructured":"Wallach J Interpretation of Diagnostic Tests: a Synopsis of Laboratory Medicine, 5th edn. 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