{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:49:06Z","timestamp":1777430946355,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>We assayed interleukin 6 (IL-6) concentrations in cerebrospinal fluid (CSF) from patients affected by meningitis of different aetiologies, and verified whether IL-6 can be used as a diagnostic marker in the differential diagnosis of meningitis. We used a monoclonal antibody enzyme immunoassay to test 98 CSF samples classified as pyogenic (15), viral (15), self-resolving aseptic meningitis (20), other infectious meningitis (9), neoplastic (4) and normal CSF from patients with (20) and without (15) non-infectious neurological diseases. CSF IL-6 concentrations were increased in pyogenic meningitis (100%) and in more than 50% of viral and other subarachnoid space infections, and rarely in patients without central nervous system infections. Though patients affected by pyogenic meningitis showed the highest levels of CSF IL-6, only a cut-off point \u226510000 pg\/mL was able to discriminate pyogenic meningitis from those of other aetiologies with a specificity \u226594% and a positive predictive value of \u22650\u00b775 but the sensitivity was \u226460%. Therefore, CSF IL-6 concentration is not a good diagnostic marker in the differential diagnosis of meningitis.<\/jats:p>","DOI":"10.1177\/000456329703400206","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"165-169","source":"Crossref","is-referenced-by-count":14,"title":["Interleukin 6 in Cerebrospinal Fluid of Patients with Meningitis is not a Useful Diagnostic Marker in the Differential Diagnosis of Meningitis"],"prefix":"10.1177","volume":"34","author":[{"given":"L F","family":"L\u00f3pez-Cort\u00e9s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cruz-Ruiz","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Laboratory, Hospital Universitario de Valme, Sevilla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"G\u00f3mez-Mateos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Jim\u00e9nez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Viciana-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Internal Medicine Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Jim\u00e9nez-Mej\u00edas","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Internal Medicine Department, Hospital Universitario Virgen del Rocio, Sevilla, 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