{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:51:47Z","timestamp":1777431107680,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>Apolipoprotein E genotypes were measured in 83 patients with familial hypercholesterolaemia (FH) and in 175 blood donor controls. Following DNA extraction from peripheral blood, each sample was genotyped for the Apo E polymorphism by polymerase chain reaction. No significant differences were found in the levels of the \u03b52 and \u03b53 alleles between the two groups, while the \u03b54 allele was approximately twice as prevalent in the FH patients as in controls ( P = 0\u00b7006, df = 1). Of the FH patients, 8\u00b74% were homozygous for the \u03b54 allele while this genotype was rare in controls ( P = 0\u00b7009, df = 1). These results suggest that the \u03b54 allele is over represented in the FH population and may contribute to increased cholesterol levels and consequent vascular disease.<\/jats:p>","DOI":"10.1177\/000456329703400507","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"534-536","source":"Crossref","is-referenced-by-count":1,"title":["APO E Genotype and Familial Hypercholesterolaemia"],"prefix":"10.1177","volume":"34","author":[{"given":"E B","family":"Duly","sequence":"first","affiliation":[{"name":"Clinical Chemistry Laboratories, Ulster Hospital, Dundonald BT16 0RH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Belfast City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C W","family":"Kirk","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Belfast City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N C","family":"Nevin","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Belfast City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T R","family":"Trinick","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratories, Ulster Hospital, Dundonald BT16 0RH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Royal Victoria Hospital, Belfast, Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I S","family":"Young","sequence":"additional","affiliation":[{"name":"Royal Victoria Hospital, Belfast, Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Belfast City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"bibr1-000456329703400507","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380010602"},{"key":"bibr2-000456329703400507","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.24.120190.001025"},{"key":"bibr3-000456329703400507","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05685-8"},{"key":"bibr4-000456329703400507","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(88)90072-X"},{"key":"bibr5-000456329703400507","doi-asserted-by":"publisher","DOI":"10.1126\/science.3513311"},{"key":"bibr6-000456329703400507","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1994.tb04007.x"},{"key":"bibr7-000456329703400507","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/39.10.2125"},{"key":"bibr8-000456329703400507","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6807.893"},{"key":"bibr9-000456329703400507","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.22.9611"},{"key":"bibr10-000456329703400507","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)43176-1","volume":"31","author":"Hixson JE","year":"1990","journal-title":"Hhal. 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