{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:09:43Z","timestamp":1793311783767,"version":"4.5.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>The serum concentrations of CA19-9 and carcinoembryonic antigen (CEA) were measured in 150 consecutive patients with histologically proven liver disease admitted to a liver unit for transplant assessment. A significant proportion of the cases studied had a CA19-9 above the upper limit of the reference range (35 kU\/L): alcoholic liver disease (73%), primary sclerosing cholangitis (61%), primary biliary cirrhosis (60%), chronic hepatitis B (71%), chronic hepatitis C (84%), autoimmune hepatitis (36%) and hepatocellular carcinoma (54%). CEA was only elevated in a small proportion of the patients with benign liver disease and the degree of elevation was small (15-37 \u03bcg\/L). Significantly raised CEA was observed in two patients (15%) with hepatocellular carcinoma. Statistically significant correlations were observed between the serum CA19-9 concentration and standard parameters of liver dysfunction: positive correlations with aspartate aminotransferase, alkaline phosphatase and bilirubin and negative correlations with albumin and \u03b3-glutamyltransferase. Positive relationships were also observed between CA19-9 and both CEA and creatinine. Both increased production of CA19-9 from biliary epithelial cells and decreased clearance due to cholestasis may be contributing to the elevation of CA19-9 in the bloodstream. Our data indicate that caution is needed in the interpretation of CA19-9 results in the presence of liver dysfunction.<\/jats:p>","DOI":"10.1177\/000456329803500113","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"99-103","source":"Crossref","is-referenced-by-count":103,"title":["The Effect of Benign and Malignant Liver Disease on the Tumour Markers CA19-9 and CEA"],"prefix":"10.1177","volume":"35","author":[{"given":"S","family":"Maestranzi","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, King's College School of Medicine and Dentistry, Bessemer Road, London SE5 9RS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Przemioslo","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies, King's College School of Medicine and Dentistry, Bessemer Road, London SE5 9RS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Oncology, Charing Cross Medical School, Fulham Palace Road, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Sherwood","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, King's College School of Medicine and Dentistry, Bessemer Road, London SE5 9RS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1998,1,1]]},"reference":[{"key":"bibr1-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.332"},{"key":"bibr2-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930520302"},{"key":"bibr3-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01449.x"},{"key":"bibr4-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537129"},{"key":"bibr5-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536670"},{"key":"bibr6-000456329803500113","first-page":"1985","volume":"48","author":"Harmenberg U","year":"1988","journal-title":"Cancer Res"},{"key":"bibr7-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(92)90053-S"},{"key":"bibr8-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.5.707"},{"key":"bibr9-000456329803500113","doi-asserted-by":"publisher","DOI":"10.3109\/00365519209088786"},{"key":"bibr10-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870115)59:2<213::AID-CNCR2820590206>3.0.CO;2-I"},{"key":"bibr11-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/31.5.687"},{"key":"bibr12-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198607000-00006"},{"key":"bibr13-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90278-0"},{"key":"bibr14-000456329803500113","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90462-X"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329803500113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329803500113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:44:07Z","timestamp":1777376647000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456329803500113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1177\/000456329803500113"],"URL":"https:\/\/doi.org\/10.1177\/000456329803500113","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}