{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:54:00Z","timestamp":1777431240270,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Clin Biochem"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>There is increasing evidence that an imbalance between products of arachidonic acid metabolism (such as prostaglandins, prostacyclin and thromboxane A2) and lipid peroxidation products might have a role in the pathogenesis of preeclampsia. In order to study some of the changes taking place in pre-eclampsia, the plasma concentrations of essential fatty acids and lipid peroxidation products [measured as thiobarbituric-acid (TBA)-reactive substance] were evaluated in 25 patients with severe pre-eclampsia and 20 normal pregnant control subjects. Arachidonic acid concentration (median and range) was significantly higher in the pre-eclamptic group (14\u00b71; 11\u00b70\u201319\u00b7 \u03bcg\/L) compared with the normal pregnant subjects (2\u00b75; 2\u00b70\u20134\u00b74 \u03bcg\/L). Plasma concentration of TBA-reactive substance was also significantly higher in the pre-eclamptic cases (14\u00b78; 13\u00b74\u201316\u00b78 vs 11\u00b74; 9\u00b70\u201312\u00b78). These results suggest that arachidonic acid and lipid peroxidation products may play a role in the pathogenesis of pre-eclampsia.<\/jats:p>","DOI":"10.1177\/000456329903600108","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T16:58:39Z","timestamp":1391619519000},"page":"62-65","source":"Crossref","is-referenced-by-count":15,"title":["Essential Fatty Acids Profile and Lipid Peroxides in Severe Pre-Eclampsia"],"prefix":"10.1177","volume":"36","author":[{"given":"Thanaa Abou","family":"Shouk","sequence":"first","affiliation":[{"name":"Biochemistry Department, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Nagib","family":"Omar","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah Taha","family":"Fayed","sequence":"additional","affiliation":[{"name":"Obstetric and Gynecology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"bibr1-000456329903600108","first-page":"1597","volume":"112","author":"Oian P","year":"1992","journal-title":"Tidsskr Nor Laegeforen"},{"key":"bibr2-000456329903600108","first-page":"337","volume":"81","author":"Garzetti GG","year":"1993","journal-title":"Obstet Gynecol"},{"key":"bibr3-000456329903600108","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(95)02153-J"},{"key":"bibr4-000456329903600108","first-page":"897","volume":"79","author":"Davidge ST","year":"1992","journal-title":"Obstet Gynecol"},{"key":"bibr5-000456329903600108","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(93)90021-4"},{"key":"bibr6-000456329903600108","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38553-9"},{"key":"bibr7-000456329903600108","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-I"},{"key":"bibr8-000456329903600108","first-page":"280","volume":"60","author":"Jendryczko A","year":"1989","journal-title":"Ginekol Pol"},{"key":"bibr9-000456329903600108","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90302-Y"},{"key":"bibr10-000456329903600108","first-page":"119","volume":"31","author":"Sane AS","year":"1989","journal-title":"Panminerva Med"},{"key":"bibr11-000456329903600108","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(92)90067-9"},{"key":"bibr12-000456329903600108","doi-asserted-by":"publisher","DOI":"10.1159\/000292616"},{"key":"bibr13-000456329903600108","doi-asserted-by":"publisher","DOI":"10.1007\/BF01076893"},{"key":"bibr14-000456329903600108","first-page":"662","volume":"30","author":"Du D","year":"1995","journal-title":"Chung Hua Fu Chan Ko Tsa Chih"},{"key":"bibr15-000456329903600108","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70336-8"}],"container-title":["Annals of Clinical Biochemistry: International Journal of Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329903600108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000456329903600108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:44:40Z","timestamp":1777376680000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000456329903600108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["10.1177\/000456329903600108"],"URL":"https:\/\/doi.org\/10.1177\/000456329903600108","relation":{},"ISSN":["0004-5632","1758-1001"],"issn-type":[{"value":"0004-5632","type":"print"},{"value":"1758-1001","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}