{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:17:04Z","timestamp":1788322624844,"version":"build-2803163510"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T00:00:00Z","timestamp":1350950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To compare the therapeutic effects of vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      plus fluoxetine and fluoxetine alone in patients with major depressive disorder.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In the present double-blind, randomized, placebo-controlled trial, 42 patients with a diagnosis of major depressive disorder based on DSM-IV criteria were randomly assigned into two groups to receive daily either 1500 IU vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      plus 20 mg fluoxetine or fluoxetine alone for 8 weeks. Depression severity was assessed at 2-week intervals using the 24-item Hamilton Depression Rating Scale (HDRS) as a primary outcome measure and the 21-item Beck Depression Inventory (BDI) as a secondary outcome measure. Serum 25(OH) vitamin D was measured at baseline and after intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Forty patients completed the trial. A two-way repeated-measures analysis of variance showed that depression severity based on HDRS and BDI decreased significantly after intervention, with a significant difference between the two groups. The vitamin D + fluoxetine combination was significantly better than fluoxetine alone from the fourth week of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In the present 8-week trial, the vitamin D + fluoxetine combination was superior to fluoxetine alone in controlling depressive symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004867412465022","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:54:25Z","timestamp":1351040065000},"page":"271-275","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":128,"title":["Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder"],"prefix":"10.1177","volume":"47","author":[{"given":"Nayereh","family":"Khoraminya","sequence":"first","affiliation":[{"name":"Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Tehrani-Doost","sequence":"additional","affiliation":[{"name":"Roozbeh Psychiatry Hospital, Department of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Jazayeri","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aghafateme","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Statistics, School of Health Management and Medical Information Sciences, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolghassem","family":"Djazayery","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,10,23]]},"reference":[{"key":"bibr1-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0348-5"},{"key":"bibr2-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1370\/afm.349"},{"key":"bibr3-0004867412465022","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.017384"},{"key":"bibr4-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.05.001"},{"key":"bibr5-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-009-0003-3"},{"key":"bibr6-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025966"},{"key":"bibr7-0004867412465022","first-page":"151","volume":"10","author":"Dumville JC","year":"2006","journal-title":"Journal of Nutrition, Health and Aging"},{"key":"bibr8-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.21.2329"},{"key":"bibr9-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.04.015"},{"key":"bibr10-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2004.08.006"},{"key":"bibr11-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70283-5"},{"key":"bibr12-0004867412465022","first-page":"5","volume":"3","author":"Gloth FM","year":"1999","journal-title":"Journal of Nutrition, Health and Aging"},{"key":"bibr13-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/22.3.447"},{"key":"bibr14-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(93)90031-B"},{"key":"bibr15-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"bibr16-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.5.508"},{"key":"bibr17-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2010.08.003"},{"key":"bibr18-0004867412465022","volume-title":"Dietary Reference Intakes for Calcium and Vitamin D","author":"Institute of Medicine","year":"2010"},{"key":"bibr19-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.02008.x"},{"key":"bibr20-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0027-5"},{"key":"bibr21-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328010ca18"},{"key":"bibr22-0004867412465022","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-4-200108210-00011"},{"key":"bibr23-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.104349"},{"key":"bibr24-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00049-5"},{"key":"bibr25-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050517"},{"key":"bibr26-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01949-4"},{"key":"bibr27-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.110"},{"key":"bibr28-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610173351602"},{"key":"bibr29-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.96"},{"key":"bibr30-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490380212"},{"key":"bibr31-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1007\/BF02247486"},{"key":"bibr32-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.087544"},{"key":"bibr33-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1007\/s007020070063"},{"key":"bibr34-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181e9bf15"},{"key":"bibr35-0004867412465022","volume-title":"The Global Burden of Diseases: 2004 update","author":"WHO","year":"2008"},{"key":"bibr36-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1097\/01.JGP.0000240986.74642.7c"},{"key":"bibr37-0004867412465022","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2703"}],"container-title":["Australian &amp; New Zealand Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004867412465022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004867412465022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004867412465022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:54:49Z","timestamp":1777373689000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004867412465022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,23]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1177\/0004867412465022"],"URL":"https:\/\/doi.org\/10.1177\/0004867412465022","relation":{},"ISSN":["0004-8674","1440-1614"],"issn-type":[{"value":"0004-8674","type":"print"},{"value":"1440-1614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,23]]}}}