{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:01:54Z","timestamp":1777413714716,"version":"3.51.4"},"reference-count":68,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Folate is one of the most widely used nutraceuticals for the treatment of mood disorders. In this article, we review folate metabolism, its relationship with bipolar disorder, and its therapeutic potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We searched PubMed and the Cochrane Library for relevant articles up to and including the year 2012. Background information, proposed mechanisms of action, and results from clinical trials were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Folate is an essential cofactor involved in methylation reactions, which are critical for monoamine synthesis and homocysteine regulation. Folate level is thought to be associated with mood disorders and limited response to antidepressants. Functional deficiency, due to a common genetic variant of the methylenetetrahydrofolate reductase (NAD(P)H) ( MTHFR) gene, could also affect the presentation of bipolar disorder. Sodium valproate and lamotrigine, commonly used mood stabilizers for the treatment of bipolar disorder, can potentially interfere with folate and homocysteine metabolism. Previous studies consistently support the efficacy of folate in the treatment of depression; one study showed efficacy in the treatment of mania. Biologically active forms of folate formulations, which do not require biochemical conversion, could be beneficial in the treatment of bipolar disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Folate augmentation could be effective for the treatment of bipolar disorder. A common genetic variant of the MTHFR gene might impact the treatment effect of folate augmentation. The biologically active form of folate could potentially correct mood stabilizer-associated functional folate deficiency, help normalize monoamine synthesis, and improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004867413502091","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T00:48:01Z","timestamp":1377218881000},"page":"1013-1018","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["One-carbon metabolism and bipolar disorder"],"prefix":"10.1177","volume":"47","author":[{"given":"Ji Hyun","family":"Baek","sequence":"first","affiliation":[{"name":"Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily E","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A","family":"Nierenberg","sequence":"additional","affiliation":[{"name":"Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"key":"bibr1-0004867413502091","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ajmg.b.20142","volume":"127","author":"Abdolmaleky HM","year":"2004","journal-title":"Am American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics"},{"key":"bibr2-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(89)90006-X"},{"key":"bibr3-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602778"},{"key":"bibr4-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.03.007"},{"key":"bibr5-0004867413502091","doi-asserted-by":"publisher","DOI":"10.3109\/10401230209147396"},{"key":"bibr6-0004867413502091","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0910"},{"key":"bibr7-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970919)74:5<526::AID-AJMG14>3.0.CO;2-E"},{"key":"bibr8-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01368.x"},{"key":"bibr9-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02303.x"},{"key":"bibr10-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.618"},{"key":"bibr11-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2012.01.013"},{"key":"bibr12-0004867413502091","first-page":"435","volume-title":"Folic Acid in Neurology, Psychiatry, and Internal Medicine","author":"Botez M","year":"1979"},{"key":"bibr13-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700038447"},{"key":"bibr14-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.69.2.228"},{"key":"bibr15-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5578.512"},{"key":"bibr16-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(90)90093-N"},{"key":"bibr17-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31101"},{"key":"bibr18-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00153-1"},{"key":"bibr19-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105048899"},{"key":"bibr20-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(86)90043-1"},{"key":"bibr21-0004867413502091","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199345050-00001"},{"key":"bibr22-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-393X(05)80187-0"},{"key":"bibr23-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1985.tb05676.x"},{"key":"bibr24-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2011.02284.x"},{"key":"bibr25-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.6.861"},{"key":"bibr26-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30665"},{"key":"bibr27-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(80)73586-7"},{"key":"bibr28-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.03.005"},{"key":"bibr29-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj347"},{"key":"bibr30-0004867413502091","unstructured":"Glaxo SmithKline (2011) Lamictal medication guide. Available at: http:\/\/us.gsk.com\/products\/assets\/us_lamictal.pdf (accessed 5 August 2013)."},{"key":"bibr31-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91942-4"},{"key":"bibr32-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2003.11.009"},{"key":"bibr33-0004867413502091","doi-asserted-by":"publisher","DOI":"10.3109\/10401239309148970"},{"key":"bibr34-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104240"},{"key":"bibr35-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.12.006"},{"key":"bibr36-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-5618.2003.00091.x"},{"key":"bibr37-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"bibr38-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.3.261"},{"key":"bibr39-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(02)00163-8"},{"key":"bibr40-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1177\/0269881104047285"},{"key":"bibr41-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000"},{"key":"bibr42-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22229"},{"key":"bibr43-0004867413502091","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m07139"},{"key":"bibr44-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852912000430"},{"key":"bibr45-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.04.005"},{"key":"bibr46-0004867413502091","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0810"},{"key":"bibr47-0004867413502091","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0811"},{"key":"bibr48-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.11071114"},{"key":"bibr49-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324128"},{"key":"bibr50-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.217"},{"key":"bibr51-0004867413502091","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0610"},{"key":"bibr52-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.06.027"},{"key":"bibr53-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1159\/000151527"},{"key":"bibr54-0004867413502091","first-page":"621","volume-title":"Advances in Epileptology: the XIIth Epilepsy International Symposium","author":"Reynolds EH","year":"1981"},{"key":"bibr55-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000193250"},{"key":"bibr56-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90650-4"},{"key":"bibr57-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.281.6247.1036"},{"key":"bibr58-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900015418"},{"key":"bibr59-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(00)00101-7"},{"key":"bibr60-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1002\/14651858"},{"key":"bibr61-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.10.3233"},{"key":"bibr62-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.262658999"},{"key":"bibr63-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.9.2737"},{"key":"bibr64-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(00)00150-9"},{"key":"bibr65-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(94)90058-2"},{"key":"bibr66-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705446"},{"key":"bibr67-0004867413502091","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)90014-0"},{"key":"bibr68-0004867413502091","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.09.59"}],"container-title":["Australian &amp; New Zealand Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004867413502091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004867413502091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004867413502091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:55:15Z","timestamp":1777373715000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004867413502091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,22]]},"references-count":68,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1177\/0004867413502091"],"URL":"https:\/\/doi.org\/10.1177\/0004867413502091","relation":{},"ISSN":["0004-8674","1440-1614"],"issn-type":[{"value":"0004-8674","type":"print"},{"value":"1440-1614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,22]]}}}