{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:23:53Z","timestamp":1792614233998,"version":"4.5.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Depression has been shown to be a risk factor for Alzheimer\u2019s disease (AD), and in older adults may provide a marker for the beginning of the prodromal phase of AD. The purpose of this systematic review is to examine the relationship between amyloid-\u03b2 (A\u03b2), a key biomarker of AD, and depression in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>The literature search was limited to studies conducted from 2006 to 2014 that were published in English in peer-reviewed journals. Studies were selected if they included a group of older adults who either met established criteria for Major Depressive Disorder or Dysthymia; or were assessed for depressive symptoms on a standardised measure. Studies were also required to include an outcome variable that was a direct measure of A\u03b2 levels in either blood or cerebrospinal fluid (CSF) samples, or via neuroimaging techniques such as positron emission tomography (PET).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Nineteen studies were identified, 15 of which found significant differences in A\u03b2 levels between depressed and non-depressed older adults. However, studies were limited by their cross-sectional design, reliance on blood-based measures of A\u03b2, and potential sample bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Future investigations should consider prospective longitudinal design using neuroimaging and CSF measures of A\u03b2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004867414557161","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T23:59:18Z","timestamp":1416527958000},"page":"36-46","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":80,"title":["Amyloid-beta and depression in healthy older adults: A systematic review"],"prefix":"10.1177","volume":"49","author":[{"given":"Karra D","family":"Harrington","sequence":"first","affiliation":[{"name":"School of Psychology, Deakin 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