{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:52:41Z","timestamp":1783011161217,"version":"3.54.6"},"reference-count":50,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC100-2314-B-006-048-MY3"],"award-info":[{"award-number":["NSC100-2314-B-006-048-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC98-2314-B-006-022-MY3"],"award-info":[{"award-number":["NSC98-2314-B-006-022-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with a first diagnosis of bipolar disorder were recruited. Symptom severity and levels of plasma cytokines (tumor necrosis factor \u03b1, C-reactive protein, interleukin 6 and transforming growth factor \u03b21) were examined during weeks 0, 1, 2, 4, 8 and 12. Neurocognitive function was evaluated at baseline and endpoint. The ALDH2 polymorphism genotype was determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 541 patients with bipolar disorder were recruited, and 355 (65.6%) completed the 12-week follow-up. A multiple linear regression analysis showed a significant ( p\u2009=\u20090.000226) association between the ALDH2 polymorphism and changes in C-reactive protein levels. Different aspects of cognitive function improved in patients with different ALDH2 genotypes. Only patients with the ALDH2*1*1 genotype showed significant correlations between improvement of cognitive function and increased transforming growth factor -\u03b21.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder. Additionally, changes in cytokine levels and cognitive function were correlated only in patients with specific ALDH2 genotypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004867417720517","type":"journal-article","created":{"date-parts":[[2017,8,5]],"date-time":"2017-08-05T01:39:35Z","timestamp":1501897175000},"page":"680-689","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study"],"prefix":"10.1177","volume":"52","author":[{"given":"Sheng-Yu","family":"Lee","sequence":"first","affiliation":[{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"},{"name":"Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan"},{"name":"Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiou-Lan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan"},{"name":"Lipid Science and Aging Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hsuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan"},{"name":"Department of Psychology, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-See","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan"},{"name":"Addiction Research Center, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, 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