{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:05:45Z","timestamp":1790751945300,"version":"4.1.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Key Characteristic Specialist Department of Shanghai Mental Health Center","award":["2013-YJTSZK-02"],"award-info":[{"award-number":["2013-YJTSZK-02"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301153"],"award-info":[{"award-number":["81301153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771460"],"award-info":[{"award-number":["81771460"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Fundamental Research Funds for the Central Universities","award":["16JXRZ12"],"award-info":[{"award-number":["16JXRZ12"]}]},{"name":"Sub-project of Shanghai Science and Technology Committee \u201cscientific and technological innovation action plan \u201d of science and technology support projects in the medicine and agricultural field","award":["15411950203"],"award-info":[{"award-number":["15411950203"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The imbalance in neurotransmitter and neuronal metabolite concentration within cortico-striato-thalamo-cortical (CSTC) circuit contributes to obsessive\u2013compulsive disorder\u2019s (OCD) onset. Previous studies showed that glutamate mediated upregulation of resting-state activity in healthy people. However, there have been few studies investigating the correlational features between functional and neurochemical alterations in OCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We utilize a combined resting-state functional magnetic resonance imaging (rs-fMRI) and proton magnetic resonance spectroscopy (\n                      <jats:sup>1<\/jats:sup>\n                      H-MRS) approach to investigate the altered functional connectivity (FC) in association with glutamatergic dysfunction in OCD pathophysiology. Three regions of interest are investigated, i.e., medial prefrontal cortex and bilateral thalamus, for seed-based whole-brain FC analysis as well as MRS data acquisition. There are 23 unmedicated adult OCD patients and 23 healthy controls recruited for brain FC analysis. Among them, 12 OCD and 8 controls are performed MRS data acquisition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Besides abnormal FC within CSTC circuit, we also find altered FCs in large-scale networks outside CSTC circuit, including occipital area and limbic and motor systems. The decreased FC between right thalamus and right middle occipital gyrus (MOG) is correlated with glutamatergic signal within right thalamus in OCD patients. Moreover, the FC between right thalamus and right dorsal anterior cingulate cortex (dACC) is associated with glutamate level in right thalamus, specifically in patient\u2019s group. Finally, the FC between right thalamus and right MOG is correlated with patient\u2019s Yale\u2013Brown Obsessive Compulsive Scale (YBOCS) compulsion and total scores, while the right thalamic glutamatergic signal is associated with YBOCS-compulsion score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings showed that the coupled intrinsic functional\u2013biochemical alterations existed both within CSTC circuit and from CSTC to occipital lobe in OCD pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004867418806370","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T11:06:11Z","timestamp":1540379171000},"page":"207-218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["The right thalamic glutamate level correlates with functional connectivity with right dorsal anterior cingulate cortex\/middle occipital gyrus in unmedicated obsessive\u2013compulsive disorder: A combined fMRI and\n                    <sup>1<\/sup>\n                    H-MRS study"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6136-6258","authenticated-orcid":false,"given":"Yongjun","family":"Chen","sequence":"first","affiliation":[{"name":"Rehabilitation Department, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Developmental Behavioral Pediatric and Children Healthcare, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Institute for Medical Imaging Technology, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Institute for Medical Imaging Technology, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Institute for Medical 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