{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:24:55Z","timestamp":1790846695640,"version":"4.1.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1059660"],"award-info":[{"award-number":["APP1059660"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1156072"],"award-info":[{"award-number":["APP1156072"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM19\/00078"],"award-info":[{"award-number":["CM19\/00078"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR17\/00003"],"award-info":[{"award-number":["JR17\/00003"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01770"],"award-info":[{"award-number":["PI16\/01770"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/01352"],"award-info":[{"award-number":["PI18\/01352"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Neurocognitive dysfunction is a common feature of bipolar disorder even in euthymia, and psychopharmacological treatment could have an effect on cognition. Long-term prescription of benzodiazepines in bipolar disorder is a common practice, and their effect on neurocognition has not been well studied in this population. The aim of this study was to evaluate the impact of concomitant benzodiazepine long-term use on neurocognitive function in stable euthymic bipolar disorder patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Seventy-three euthymic bipolar disorder outpatients and 40 healthy individuals were assessed using a neurocognitive battery. Patients were classified in two groups according to the presence of benzodiazepines in their treatment: the benzodiazepine group ( n\u2009=\u200934) and the non- benzodiazepine group ( n\u2009=\u200939). Neurocognitive performance was compared between the groups using a multivariate analysis of covariance, considering age, number of depressive episodes, adjuvant antipsychotic drugs, Young Mania Rating Scale score and Hamilton Depression Rating Scale score as covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Both bipolar disorder groups (benzodiazepine and non-benzodiazepine) showed an impairment in memory domains (Immediate Visual Memory [ p\u2009=\u20090.013], Working Memory [ p\u2009&lt;\u20090.001], and Letter-Number Sequence [ p\u2009&lt;\u20090.001] from the Wechsler Memory Scale-Revised-III) and slower processing speed functions (Stroop Colour [ p\u2009&lt;\u20090.001]) relative to the control group. Nevertheless, the benzodiazepine group showed a greater impairment in executive functions (Conceptual Level Responses [ p\u2009=\u20090.024] from the Wisconsin Card Sorting Test and Frontal Assessment Battery [ p\u2009=\u20090.042]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although memory and processing speed impairments were found in bipolar disorder, regardless of their benzodiazepine treatment, benzodiazepine users presented additional neurocognitive impairments in terms of executive functioning. These findings support restricted prescription of benzodiazepines in individuals with bipolar disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0004867420969819","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T21:03:59Z","timestamp":1604696639000},"page":"1005-1016","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["The effect of concomitant benzodiazepine use on neurocognition in stable, long-term patients with bipolar disorder"],"prefix":"10.1177","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5942-5044","authenticated-orcid":false,"given":"Yolanda","family":"Ca\u00f1ada","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sabater","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-5608","authenticated-orcid":false,"given":"Pilar","family":"Sierra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain"},{"name":"Department of Medicine, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-7396","authenticated-orcid":false,"given":"Vicent","family":"Balanz\u00e1-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain"},{"name":"Department of Medicine, University of Valencia, Valencia, Spain"},{"name":"Center of Biomedical Investigation Network in Mental Health (CIBERSAM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-6946","authenticated-orcid":false,"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia"},{"name":"Orygen \u2013 The National Centre for Excellence in Youth Mental Health, Parkville, VIC, Australia"},{"name":"Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia"},{"name":"Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seetal","family":"Dodd","sequence":"additional","affiliation":[{"name":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia"},{"name":"Orygen \u2013 The National Centre for Excellence in Youth Mental Health, Parkville, VIC, Australia"},{"name":"Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Naval\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain"},{"name":"Neonatal Research Unit, La Fe Health Research Institute, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Livianos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain"},{"name":"Department of Medicine, University of Valencia, Valencia, Spain"},{"name":"CIBERESP-17, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garc\u00eda-Blanco","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, La Fe University and Polytechnic Hospital, Valencia, Spain"},{"name":"Neonatal Research Unit, La Fe Health Research Institute, Valencia, Spain"},{"name":"Department of Personality, Evaluation, and Psychological Treatments, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"bibr1-0004867420969819","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000","edition":"4"},{"key":"bibr2-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-016-0711-8"},{"key":"bibr3-0004867420969819","first-page":"108","volume":"6","author":"Balanz\u00e1-Mart\u00ednez V","year":"2015","journal-title":"Frontiers in Physiology"},{"key":"bibr4-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.10.018"},{"key":"bibr5-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12341"},{"key":"bibr6-0004867420969819","first-page":"363","volume":"32","author":"Benavent P","year":"2004","journal-title":"Actas Espa\u00f1olas de Psiquiatr\u00eda"},{"key":"bibr7-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20441"},{"key":"bibr8-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000257"},{"key":"bibr9-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-011-1047-y"},{"key":"bibr10-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.09.007"},{"key":"bibr11-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.009"},{"key":"bibr12-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12133"},{"key":"bibr13-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718004038"},{"key":"bibr14-0004867420969819","doi-asserted-by":"publisher","DOI":"10.2174\/1381612023396654"},{"key":"bibr15-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7753(02)73419-2"},{"key":"bibr16-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.03.041"},{"key":"bibr17-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acx120"},{"key":"bibr18-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-016-2732-5"},{"key":"bibr19-0004867420969819","first-page":"83","volume":"27","author":"Fern\u00e1ndez A","year":"2002","journal-title":"Revista Neurol\u00f3gica Argentina"},{"key":"bibr20-0004867420969819","volume-title":"Entrevista Cl\u00ednica Estructurada Para Los Trastornos Del Eje I Del DSM-IV: SCID-I. Versi\u00f3n Cl\u00ednica (SCID-I-VC)","author":"First M","year":"1997"},{"key":"bibr21-0004867420969819","volume-title":"Test de Colores y Palabras de Stroop (Manual)","author":"Golden CJ","year":"2001"},{"key":"bibr22-0004867420969819","volume-title":"The Spanish Version of the Scl-90-r: Normative Data in the General Population","author":"Gonz\u00e1lez de","year":"1989"},{"key":"bibr23-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12847"},{"key":"bibr24-0004867420969819","volume-title":"Test de Clasificaci\u00f3n de Tarjetas de Wisconsin","author":"Grant DA","year":"2001"},{"key":"bibr25-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1177\/107319119700400305"},{"key":"bibr26-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207698"},{"key":"bibr27-0004867420969819","doi-asserted-by":"publisher","DOI":"10.2165\/11310850-000000000-00000"},{"key":"bibr28-0004867420969819","unstructured":"Livianos L, Pino A, Sierra P (2003) Gr\u00e1fico del Estado de \u00c1nimo para pacientes Bipolares. Madrid: Ed Emisa, p. 10."},{"key":"bibr29-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178503"},{"key":"bibr30-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00327.x"},{"key":"bibr31-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.12.232"},{"key":"bibr32-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbaa024"},{"key":"bibr33-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0305-4"},{"key":"bibr34-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716003135"},{"key":"bibr35-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acp041"},{"key":"bibr36-0004867420969819","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05019yel"},{"key":"bibr37-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(88)90024-6"},{"key":"bibr38-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.10.008"},{"key":"bibr39-0004867420969819","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v9.i1.7"},{"key":"bibr40-0004867420969819","first-page":"9","volume":"66","author":"Stewart SA","year":"2005","journal-title":"Journal of Clinical Psychiatry"},{"key":"bibr41-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.12.234"},{"key":"bibr42-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.01.004"},{"key":"bibr43-0004867420969819","first-page":"109","volume":"22","author":"V\u00e1zquez-Barquero JL","year":"1994","journal-title":"Actas Luso-Espa\u00f1olas de Neurolog\u00eda, Psiquiatr\u00eda y Ciencias Afines"},{"key":"bibr44-0004867420969819","first-page":"301","volume":"30","author":"Vieta E","year":"2002","journal-title":"Actas Espa\u00f1olas de Psiquiatr\u00eda"},{"key":"bibr45-0004867420969819","volume-title":"Wechsler Memory Scale","author":"Wechsler D","year":"1997","edition":"3"},{"key":"bibr46-0004867420969819","volume-title":"Wechsler Adult Intelligence Scale-III: Technical Manual","author":"Wechsler D","year":"2001"},{"issue":"2","key":"bibr47-0004867420969819","first-page":"151","volume":"44","author":"Woods JH","year":"1992","journal-title":"Pharmacological reviews"},{"key":"bibr48-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181e049ca"},{"key":"bibr49-0004867420969819","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12025"}],"container-title":["Australian &amp; New Zealand Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004867420969819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0004867420969819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0004867420969819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:55:11Z","timestamp":1777373711000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0004867420969819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1177\/0004867420969819"],"URL":"https:\/\/doi.org\/10.1177\/0004867420969819","relation":{},"ISSN":["0004-8674","1440-1614"],"issn-type":[{"value":"0004-8674","type":"print"},{"value":"1440-1614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,6]]}}}