{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:19:14Z","timestamp":1783955954912,"version":"3.55.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Yulgilbar Alzheimer\u2019s Research Program"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Amyloid-beta often co-exists in dementia with Lewy bodies, but its clinical relevance in dementia with Lewy bodies remains unclear. This study aimed to investigate the clinical and imaging correlates of amyloid-beta deposition in dementia with Lewy bodies, particularly its relationship with cortical thickness in Alzheimer\u2019s disease\u2013prone regions and hippocampal volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty-four participants with probable dementia with Lewy bodies underwent high-resolution magnetic resonance imaging and amyloid-beta positron emission tomography imaging using the radiotracer\n                      <jats:sup>18<\/jats:sup>\n                      F-NAV4694. Amyloid-beta deposition was quantified and reported using the Centiloid method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Amyloid-beta positivity, defined as Centiloid\u2009&gt;\u200950, was present in 45.8% of dementia with Lewy bodies participants. There were no statistically significant differences in clinical characteristics between A\u03b2+ and A\u03b2\u2212 dementia with Lewy bodies. Compared with the A\u03b2\u2212 group, A\u03b2+ dementia with Lewy bodies exhibited greater global cortical thinning as well as in the Alzheimer\u2019s disease\u2013prone region of interest, adjusted for age, sex and years of education. A mean cortical thickness of 5.12\u2009mm across a combined meta-region of interest has a sensitivity of 88.9% and specificity of 90.0% in discriminating A\u03b2+ from A\u03b2\u2212 dementia with Lewy bodies. Hippocampal volume was not different between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early structural changes in cortical thickness, but not hippocampal volume, were observed in dementia with Lewy bodies with significant amyloid-beta burden. This may represent an early Alzheimer\u2019s disease\u2013related neurodegenerative process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00048674221081773","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T03:36:48Z","timestamp":1645673808000},"page":"594-602","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between amyloid-beta deposition and cortical thickness in dementia with Lewy bodies"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3384-3499","authenticated-orcid":false,"given":"Kai Sin","family":"Chin","sequence":"first","affiliation":[{"name":"Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia"},{"name":"Department of Aged Care, The Royal Melbourne Hospital, Parkville, VIC, Australia"},{"name":"Population Health and Immunity Division, The 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