{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:37:47Z","timestamp":1792046267948,"version":"4.4.0"},"reference-count":87,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Attention deficit hyperactivity disorder is a frequent comorbid condition in adults with bipolar disorder. We performed a meta-analysis aimed at assessing sociodemographic and clinical correlates of attention deficit hyperactivity disorder in bipolar disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We searched main electronic databases up to June 2021. Random-effects meta-analyses, with relevant meta-regression and quality-based sensitivity analyses, were carried out to estimate the association between attention deficit hyperactivity disorder and putative correlates, grading the quality of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We included 43 studies, based on 38 independent samples. Attention deficit hyperactivity disorder participants were more likely to be males (odds ratio\u2009=\u20091.46; p\u2009&lt;\u20090.001) and unemployed (odds ratio\u2009=\u20091.45; p\u2009=\u20090.045), and less likely to be married (odds ratio\u2009=\u20090.62; p\u2009=\u20090.014). They had an earlier onset of bipolar disorder (standardized mean difference\u2009=\u2009\u22120.36; p\u2009&lt;\u20090.001); more mood episodes (standardized mean difference\u2009=\u20090.35; p\u2009=\u20090.007), particularly depressive (standardized mean difference\u2009=\u20090.30; p\u2009=\u20090.011) and mixed (standardized mean difference\u2009=\u20090.30; p\u2009=\u20090.031) ones; higher odds of using antidepressants (odds ratio\u2009=\u20091.80; p\u2009=\u20090.024) and attempted suicides (odds ratio\u2009=\u20091.83; p\u2009&lt;\u20090.001) and lower odds of psychotic features (odds ratio\u2009=\u20090.63; p\u2009=\u20090.010). Moreover, they were more likely to have generalized anxiety disorder (odds ratio\u2009=\u20091.50; p\u2009=\u20090.019), panic disorder (odds ratio\u2009=\u20091.89; p\u2009&lt;\u20090.001), social phobia (odds ratio\u2009=\u20091.61; p\u2009=\u20090.017), eating disorders (odds ratio\u2009=\u20091.91; p\u2009=\u20090.007), antisocial personality disorder (odds ratio\u2009=\u20093.59; p\u2009=\u20090.004) and substance (odds ratio\u2009=\u20092.29; p\u2009&lt;\u20090.001) or alcohol (odds ratio\u2009=\u20092.28; p\u2009&lt;\u20090.001) use disorders. Quality of the evidence was generally low or very low for the majority of correlates, except for bipolar disorder onset and alcohol\/substance use disorders (high), and suicide attempts (moderate).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Comorbid bipolar disorder\/attention deficit hyperactivity disorder may have some distinctive clinical features including an earlier onset of bipolar disorder and higher comorbid alcohol\/substance use disorder rates. Further research is needed to identify additional clinical characteristics of this comorbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00048674221106669","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T05:25:00Z","timestamp":1656739500000},"page":"34-48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2612-4119","authenticated-orcid":false,"given":"Francesco","family":"Bartoli","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-5331","authenticated-orcid":false,"given":"Tommaso","family":"Callovini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Cavaleri","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo Matteo","family":"Cioni","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Bachi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Moretti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2718-4076","authenticated-orcid":false,"given":"Aurelia","family":"Canestro","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Morreale","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Nasti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Palpella","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8184-2634","authenticated-orcid":false,"given":"Susanna","family":"Piacenti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Nacinovich","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Riboldi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-2107","authenticated-orcid":false,"given":"Cristina","family":"Crocamo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carr\u00e0","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy"},{"name":"Division of Psychiatry, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"bibr1-00048674221106669","first-page":"3318","volume":"9","author":"Aksoy SN","year":"2010","journal-title":"African Journal of Biotechnology"},{"key":"bibr2-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-013-0393-4"},{"key":"bibr3-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2014.915800"},{"key":"bibr4-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1080\/10177833.2010.11790636"},{"key":"bibr5-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.13120"},{"key":"bibr6-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13040447"},{"key":"bibr7-00048674221106669","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12010038"},{"key":"bibr8-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1177\/0269881117749851"},{"key":"bibr9-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1080\/17542863.2016.1228686"},{"key":"bibr10-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-019-0169-5"},{"key":"bibr11-00048674221106669","doi-asserted-by":"publisher","DOI":"10.4274\/npa.y6376"},{"key":"bibr12-00048674221106669","doi-asserted-by":"publisher","DOI":"10.3109\/15622971003653238"},{"key":"bibr13-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707001791"},{"key":"bibr14-00048674221106669","first-page":"23","volume":"24","author":"Bond DJ","year":"2012","journal-title":"Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists"},{"key":"bibr15-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.06.033"},{"key":"bibr16-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1159\/000090429"},{"key":"bibr17-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1906193"},{"key":"bibr18-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15070988"},{"key":"bibr19-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0258(20001130)19:22<3127::AID-SIM784>3.0.CO;2-M"},{"key":"bibr20-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"bibr21-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-013-0456-6"},{"key":"bibr22-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"bibr23-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12899"},{"key":"bibr24-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.10.021"},{"key":"bibr25-00048674221106669","doi-asserted-by":"publisher","DOI":"10.31661\/gmj.v2i4.45"},{"key":"bibr26-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.170097"},{"key":"bibr27-00048674221106669","doi-asserted-by":"publisher","DOI":"10.11606\/s1518-8787.20190530012356"},{"key":"bibr28-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.11.109"},{"key":"bibr29-00048674221106669","doi-asserted-by":"publisher","DOI":"10.5152\/npa.2015.11328"},{"key":"bibr30-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12024"},{"key":"bibr31-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e328331f694"},{"key":"bibr32-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.09.001"},{"key":"bibr33-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"bibr34-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2018.05.015"},{"key":"bibr35-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2012.11.005"},{"key":"bibr36-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12867"},{"key":"bibr37-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.06.036"},{"key":"bibr38-00048674221106669","doi-asserted-by":"publisher","DOI":"10.5455\/bcp.20121130090435"},{"key":"bibr39-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.02.007"},{"key":"bibr40-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-019-09402-x"},{"key":"bibr41-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.11.003"},{"key":"bibr42-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.113988"},{"key":"bibr43-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31544-0"},{"key":"bibr44-00048674221106669","volume":"12","author":"McIntyre RS","year":"2010","journal-title":"Primary Care Companion to the Journal of Clinical Psychiatry"},{"key":"bibr45-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.12"},{"key":"bibr46-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1177\/1087054713515748"},{"key":"bibr47-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14101266"},{"key":"bibr48-00048674221106669","doi-asserted-by":"publisher","DOI":"10.2174\/0929867326666190805153610"},{"key":"bibr49-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.01.036"},{"key":"bibr50-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0613-z"},{"key":"bibr51-00048674221106669","doi-asserted-by":"publisher","DOI":"10.5455\/apd.37031"},{"key":"bibr52-00048674221106669","volume":"372","author":"Page MJ","year":"2021","journal-title":"British Medical Journal"},{"key":"bibr53-00048674221106669","first-page":"349","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.2","author":"Page MJ","year":"2021"},{"key":"bibr54-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn065"},{"key":"bibr55-00048674221106669","doi-asserted-by":"publisher","DOI":"10.4103\/2349-5006.196325"},{"key":"bibr56-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.06.053"},{"key":"bibr57-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.12.010"},{"key":"bibr58-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1177\/1087054715618788"},{"key":"bibr59-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.09.038"},{"key":"bibr60-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2019.1619182"},{"key":"bibr61-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2017.1351878"},{"key":"bibr62-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.07.060"},{"key":"bibr63-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1300\/J079v21n04_02"},{"key":"bibr64-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0300-3"},{"key":"bibr65-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01399.x"},{"key":"bibr66-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.466"},{"key":"bibr67-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-019-0149-9"},{"key":"bibr68-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13283"},{"key":"bibr69-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-007-0054-2"},{"key":"bibr70-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.01.017"},{"key":"bibr71-00048674221106669","first-page":"375","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.2","author":"Sch\u00fcnemann HJ","year":"2021"},{"key":"bibr72-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111412095"},{"key":"bibr73-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.06.016"},{"key":"bibr74-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.04.003"},{"key":"bibr75-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12543"},{"key":"bibr76-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2010.00806.x"},{"key":"bibr77-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-008-0807-x"},{"key":"bibr78-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.09.037"},{"key":"bibr79-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12426"},{"key":"bibr80-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.08.019"},{"key":"bibr81-00048674221106669","first-page":"107","volume":"48","author":"T\u00fcys\u00fczo\u011flu H","year":"2011","journal-title":"N\u00f6ropsikiyatri Ar\u015fivi"},{"key":"bibr82-00048674221106669","doi-asserted-by":"publisher","DOI":"10.2174\/1745017901915010160"},{"key":"bibr83-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.08.040"},{"key":"bibr84-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.08.017"},{"key":"bibr85-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2015.05.005"},{"key":"bibr86-00048674221106669","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2850.2010.01226.x"},{"key":"bibr87-00048674221106669","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2009.11.1\/fdzepf"}],"container-title":["Australian &amp; New Zealand Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00048674221106669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00048674221106669","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00048674221106669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:56:31Z","timestamp":1777373791000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00048674221106669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1177\/00048674221106669"],"URL":"https:\/\/doi.org\/10.1177\/00048674221106669","relation":{},"ISSN":["0004-8674","1440-1614"],"issn-type":[{"value":"0004-8674","type":"print"},{"value":"1440-1614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,2]]}}}