{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:20:07Z","timestamp":1793751607768,"version":"4.6.1"},"reference-count":91,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Binge spectrum disorders are prevalent worldwide. Psychiatric and medical comorbidities are common, and societal costs are significant. Evidence-based treatment remains underutilized. Cognitive behavioral therapy is the recommended first-line treatment, but pharmacotherapy may be easier to access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Meta-analytic evidence directly comparing cognitive behavioral therapy with pharmacotherapy is lacking. We aimed to compare the effects of cognitive behavioral therapy interventions with any pharmacological treatment for binge spectrum disorders. We searched PubMed, Embase, CENTRAL, ClinicalTrials.gov and reference lists for randomized controlled trials comparing cognitive behavioral therapy with any pharmacotherapy for bulimia nervosa\/binge eating disorder and performed pairwise meta-analytic evaluations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary Outcomes:<\/jats:title>\n                    <jats:p>Primary outcomes are remission and frequency of binges. Secondary outcomes are frequency of purges, response, eating disorder psychopathology, weight\/body mass index, depression, anxiety, quality of life and dropouts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Eleven randomized controlled trials comparing cognitive behavioral therapy with fluoxetine\/imipramine\/desipramine\/methylphenidate\/sibutramine were identified (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009531). Cognitive behavioral therapy was superior to antidepressants in terms of remission, frequency of binges and eating disorder psychopathology. There were no statistically significant differences for any of the individual cognitive behavioral therapy vs drug comparisons in terms of response\/depression\/anxiety\/weight\/quality of life\/dropouts. Cognitive behavioral therapy was not superior to sibutramine\/methylphenidate for the primary outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00048674231219593","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T04:54:26Z","timestamp":1704430466000},"page":"308-319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis"],"prefix":"10.1177","volume":"58","author":[{"given":"Myrto T","family":"Samara","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, Greece"},{"name":"Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki","family":"Michou","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social &amp; Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas S","family":"Lappas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, Greece"},{"name":"Aneurin Bevan University Health Board, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Argyrou","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social &amp; Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissavet","family":"Mathioudaki","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social &amp; Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra Rafailia","family":"Bakaloudi","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social &amp; Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Tsekitsidi","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social &amp; Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-6728","authenticated-orcid":false,"given":"Zoi A","family":"Polyzopoulou","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Western Macedonia, Florina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, University of Thessaly, Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Papazisis","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Chourdakis","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social &amp; Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"e_1_3_2_2_1","first-page":"433","article-title":"Pharmacotherapy of bulimia nervosa and binge eating disorder: Long-term outcomes","volume":"33","author":"Agras WS","year":"1997","unstructured":"Agras WS (1997) Pharmacotherapy of bulimia nervosa and binge eating disorder: Long-term outcomes. 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