{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:56:42Z","timestamp":1792637802234,"version":"4.5.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Aust N Z J Psychiatry"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>There is mounting evidence for the use of ketamine\/esketamine in the treatment of depression. This paper examines how comorbid borderline personality disorder, or traits, may impact the efficacy of ketamine\/esketamine in the treatment of depressive disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To evaluate the efficacy of ketamine\/esketamine in the treatment of depression where there are comorbid borderline personality disorder\/traits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>MEDLINE, Embase, APA PsycInfo, CINAHL and Scopus databases were searched for English language journal articles focusing on the use of ketamine\/esketamine to treat depression in patients with comorbid borderline personality disorder\/traits. Analysis included study design and intervention, efficacy statistics relating to the treatment of depression, as well as study limitations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Nine studies (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009281) were included. Ultimately, patients with depression and comorbid borderline personality disorder\/traits were equally likely to respond to ketamine\/esketamine as those with depression but without borderline personality disorder\/traits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This is the first systematic review to assess the effectiveness of ketamine\/esketamine in this cohort. Our findings suggest that ketamine\/esketamine may be useful in improving symptoms of depression, in those with comorbid borderline personality disorder. Limited study data are available; however, given case reports of suicidal ideation and self-harm following treatment cessation, as well as indications of a higher risk of acute dissociation in individuals with borderline personality disorder, clinicians should exercise caution when using ketamine to treat depression in this population. More data are required including a larger randomised control trial to assess the efficacy and side effects of ketamine\/esketamine in this study population. Clinicians should, where available and appropriate, consider offering ketamine\/esketamine to patients in this cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00048674251374472","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T10:06:54Z","timestamp":1758362814000},"page":"1046-1058","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ketamine\/esketamine in the treatment of depression with comorbid borderline personality disorder or traits: A systematic review of effectiveness"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0571-5860","authenticated-orcid":false,"given":"Emma","family":"Scott","sequence":"first","affiliation":[{"name":"West Moreton Mental Health Service, Queensland Health, Ipswich, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5220-9557","authenticated-orcid":false,"given":"Don Thomas","family":"Thekkuden","sequence":"additional","affiliation":[{"name":"West Moreton Mental Health Service, Queensland Health, Ipswich, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-3183","authenticated-orcid":false,"given":"Katelyn","family":"Kerr","sequence":"additional","affiliation":[{"name":"Gallipoli Medical Research Foundation, Brisbane, QLD, Australia"},{"name":"Savoir Rooms, Milton, NSW, Australia"},{"name":"Australian Institute for Suicide Research and Prevention, Griffith University, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Meurk","sequence":"additional","affiliation":[{"name":"Gallipoli Medical Research Foundation, Brisbane, QLD, Australia"},{"name":"School of Public Health, The University of Queensland, Brisbane, QLD, Australia"},{"name":"Queensland Centre for Mental Health Research, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","unstructured":"Abdallah CG Averill LA Collins KA et al. 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