{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:49:50Z","timestamp":1777524590501,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>A polymerase chain reaction kit (AMPLICOR EV\u00ae) for the detection of enteroviruses (EV-PCR) in the cerebrospinal fluid (CSF) was evaluated in clinical conditions in a prospective blinded-intention study. Forty-three children (mean age 2.7 years) hospitalized for suspected meningitis or fever of unclear etiology were enrolled. EV-PCR was performed on a daily basis. Results were available in less than 2 days in 72% of cases. EV-PCR was positive in nine (21%) children, including three infants without CSF pleocytosis. Knowing their EV-PCR result would have allowed a saving of 18 hospital days and 12 days of antibiotic therapy. The EV-PCR in the CSF can thus be practically useful for children hospitalized for meningitis or fever if available on-site on a daily basis.<\/jats:p>","DOI":"10.1177\/000992280003900402","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:21:41Z","timestamp":1182460901000},"page":"203-208","source":"Crossref","is-referenced-by-count":23,"title":["Detection of Enteroviruses in the Cerebrospinal Fluid by Polymerase Chain Reaction: Prospective Study of Impact on the Management of Hospitalized Children"],"prefix":"10.1177","volume":"39","author":[{"given":"Virginie Masserey","family":"Spicher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Yves","family":"Berclaz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Cheseaux","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Alain","family":"Morandi","sequence":"additional","affiliation":[{"name":"Children's Hospital, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Suter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Wunderli","sequence":"additional","affiliation":[{"name":"Children's Hospital, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire-Anne","family":"Siegrist","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.971"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82451-5"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.30.1.160-165.1992"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.32.10.2590-2592.1994"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.34.1.199-201.1996"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199403000-00002"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1542\/peds.94.2.157","volume":"94","author":"Schlesinger Y","year":"1994","journal-title":"Pediatrics"},{"key":"atypb8","volume-title":"Four-year experience with enterovirus polymerase chain reaction for the routine diagnosis of viral meningitis in children","author":"Espina R","year":"1998"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80566-3"},{"key":"atypb10","first-page":"889","volume":"139","author":"Krober MS","year":"1985","journal-title":"ADC"},{"key":"atypb11","first-page":"454","volume":"141","author":"Wildin S","year":"1987","journal-title":"AJDC"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1996.02170340033006"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.34.12.3002-3006.1996"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80866-3"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992280003900402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992280003900402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:23:48Z","timestamp":1777393428000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992280003900402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1177\/000992280003900402"],"URL":"https:\/\/doi.org\/10.1177\/000992280003900402","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}