{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:35:02Z","timestamp":1778600102186,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pediatr (Phila)"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Toxic epidermal necrolysis (TEN) is a relatively rare disease, characterized by generalized erythema, bulla formation, and exfoliation of the epidermis that resembles scalding. It is usually drug-induced and mediated by immune reactions of several types. TEN has to be differentiated from erythema multiforme and Stevens-Johnson syndrome. TEN bears a life-threatening potential and a risk for significant complications such as dehydration; secondary infections; pulmonary, gastrointestinal, and renal involvement; and late scarring with cosmetic and functional implications. Therapeutic interventions include admission in a burn center unit, systemic antibiotics and corticosteroids, topical therapy with antibacterial agents and biological dressings, and supportive measures.<\/jats:p>","DOI":"10.1177\/000992280003901201","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:21:41Z","timestamp":1182460901000},"page":"687-694","source":"Crossref","is-referenced-by-count":24,"title":["Toxic Epidermal Necrolysis in Children\u2014An Update"],"prefix":"10.1177","volume":"39","author":[{"given":"Mihaela","family":"Ringheanu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Maimonides Medical Center, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresita A.","family":"Laude","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Dermatology, Division of Pediatric Dermatology, State University of New York, Health Science Center at Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"atypb1","first-page":"344","volume":"49","author":"Hamilton ES","year":"1926","journal-title":"Ill Med J"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1956.tb12766.x"},{"key":"atypb3","first-page":"97","volume":"30","author":"Lang R","year":"1956","journal-title":"S Afr Med j"},{"key":"atypb4","first-page":"972","volume-title":"Pediatric Dermatology","author":"Lynch PJ","year":"1995","edition":"2"},{"key":"atypb5","first-page":"587","volume-title":"Dermatology","author":"Millikan LE","year":"1992","edition":"3"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70207-1"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660330082014"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670250049006"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670250043005"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb02356.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690050073012"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199601000-00008"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680270059007"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1159\/000233856"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199704000-00005"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1995.tb01420.x"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050492"},{"issue":"3","key":"atypb18","first-page":"236","volume":"11","author":"Dasgupta A","year":"1994","journal-title":"Otorynolaryngology"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90297-2"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb02806.x"},{"key":"atypb21","first-page":"305","volume":"36","author":"Parsonsj M","year":"1985","journal-title":"Cutis"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199809020-00014"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199711000-00009"},{"key":"atypb24","first-page":"340","volume":"180","author":"Kelemen Mj","year":"1995","journal-title":"J Am Coll Surg"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(90)90165-S"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80736-X"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199005000-00010"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70051-6"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb01674.x"},{"key":"atypb30","first-page":"85","volume-title":"Clinical Burn Therapy, A Management and Prevention Guide","author":"Hummell RP","year":"1982"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(89)80240-4"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1177\/039139889101401006"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00192.x"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70497-4"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5388.490"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb01167.x"},{"key":"atypb37","first-page":"267","volume":"38","author":"Ruocco V","year":"1986","journal-title":"Cutis"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1177\/011542659701200281"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992280003901201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992280003901201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:23:39Z","timestamp":1777393419000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992280003901201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["10.1177\/000992280003901201"],"URL":"https:\/\/doi.org\/10.1177\/000992280003901201","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}