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The primary-care physician has an important role in caring for these individuals and their families by providing anticipatory guidance regarding issues relating to endocrinology, behavior, development, and preventive medical care. Furthermore, the primarycare giver can serve as a valuable source of support and advocacy for the family of a boy with Klinefelter syndrome. We review the current state of knowledge regarding Klinefelter syndrome and its variants, with an emphasis on medical and early developmental interventions.<\/jats:p>","DOI":"10.1177\/000992280104001201","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:21:41Z","timestamp":1182460901000},"page":"639-651","source":"Crossref","is-referenced-by-count":80,"title":["Kilnefelter Syndrome and Its Variants: An Update and Review for the Primary Pediatrician"],"prefix":"10.1177","volume":"40","author":[{"given":"Jeannie","family":"Visootsak","sequence":"first","affiliation":[{"name":"Division of Child Development, Department of Pediatrics, King-Drew Medical Center, UCLA School of Medicine, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Aylstock","sequence":"additional","affiliation":[{"name":"Klinefelter Syndrome and Associates, P.O. 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