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Transient patent ductus arteriosus was more commonly seen in Group I. Presence of a patent foramen ovale, failure to return for follow-up, and surgical mortality rate did not differ between the 2 groups. A more selective policy related to timing of the initial echocardiogram in asymptomatic infants with trisomy 21 appears to be warranted.<\/jats:p>","DOI":"10.1177\/000992280504400104","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T16:28:22Z","timestamp":1143822502000},"page":"39-42","source":"Crossref","is-referenced-by-count":4,"title":["Trisomy 21 and Congenital Heart Disease: Effect of Timing of Initial Echocardiogram"],"prefix":"10.1177","volume":"44","author":[{"given":"Sadia","family":"Ghaffar","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S.","family":"Lemler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Fixler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Ramaciotti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"atypb1","first-page":"617","volume":"43","year":"1994","journal-title":"MMWR"},{"key":"atypb2","first-page":"203","volume-title":"Down Syndrome: Advances in Biomedicine and the Behavioral Sciences","author":"Pueschel SM","year":"1982"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70372-5"},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1542\/peds.93.5.855","volume":"93","author":"American Academy of Pediatrics","year":"1994","journal-title":"Pediatrics"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19981116)80:3<213::AID-AJMG6>3.0.CO;2-8"},{"key":"atypb6","first-page":"44","volume":"41","author":"Stoll C","year":"1998","journal-title":"Ann Genet"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980605)77:5<431::AID-AJMG15>3.0.CO;2-J"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.3104\/reports.104"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200575"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1079"},{"key":"atypb11","first-page":"70","volume":"43","author":"Lai FM","year":"2002","journal-title":"Singapore Med J"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/tera.10042","volume":"65","author":"Forrester MB","year":"2002","journal-title":"Teratology"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6790.1425"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199407000-00010"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320430620"}],"container-title":["Clinical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992280504400104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/000992280504400104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:25:58Z","timestamp":1777393558000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/000992280504400104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1177\/000992280504400104"],"URL":"https:\/\/doi.org\/10.1177\/000992280504400104","relation":{},"ISSN":["0009-9228","1938-2707"],"issn-type":[{"value":"0009-9228","type":"print"},{"value":"1938-2707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}