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The primary objective was to compare the mean composite symptom score (CSS) at week 8 with baseline after treatment with 20 or 40 mg of pantoprazole. Statistically significant (p &lt; 0.001) improvement in CSS occurred in both groups. Safety was comparable between the 2 groups. Pantoprazole was safe, well tolerated, and effective in reducing symptoms of GERD in adolescents.<\/jats:p>","DOI":"10.1177\/0009922806292792","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:21:41Z","timestamp":1182460901000},"page":"741-749","source":"Crossref","is-referenced-by-count":28,"title":["Multicenter, Randomized, Double-Blind Study Comparing 20 and 40 mg of Pantoprazole for Symptom Relief in Adolescents (12 to 16 Years of Age) with Gastroesophageal Reflux Disease (GERD)"],"prefix":"10.1177","volume":"45","author":[{"given":"V. 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